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Maternal adversities during pregnancy and cord blood oxytocin receptor (OXTR) DNA methylation

Maternal adversities during pregnancy and cord blood oxytocin receptor (OXTR) DNA methylation

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UNTERNAEHRER, Eva, Margarete BOLTEN, Irina NAST, Simon STAEHLI, Andrea H. MEYER, Emma DEMPSTER, Dirk H. HELLHAMMER, Roselind LIEB, Gunther MEINLSCHMIDT, 2016. Maternal adversities during pregnancy and cord blood oxytocin receptor (OXTR) DNA methylation. In: Social Cognitive and Affective Neuroscience (SCAN). 11(9), pp. 1460-1470. ISSN 1749-5016. eISSN 1749-5024. Available under: doi: 10.1093/scan/nsw051

@article{Unternaehrer2016Mater-44830, title={Maternal adversities during pregnancy and cord blood oxytocin receptor (OXTR) DNA methylation}, year={2016}, doi={10.1093/scan/nsw051}, number={9}, volume={11}, issn={1749-5016}, journal={Social Cognitive and Affective Neuroscience (SCAN)}, pages={1460--1470}, author={Unternaehrer, Eva and Bolten, Margarete and Nast, Irina and Staehli, Simon and Meyer, Andrea H. and Dempster, Emma and Hellhammer, Dirk H. and Lieb, Roselind and Meinlschmidt, Gunther} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/44830"> <dc:creator>Unternaehrer, Eva</dc:creator> <dc:contributor>Nast, Irina</dc:contributor> <dcterms:rights rdf:resource="https://kops.uni-konstanz.de/page/termsofuse"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-02-04T14:47:41Z</dc:date> <dc:rights>terms-of-use</dc:rights> <dc:contributor>Meinlschmidt, Gunther</dc:contributor> <dc:language>eng</dc:language> <dcterms:issued>2016</dcterms:issued> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/44830"/> <dc:contributor>Staehli, Simon</dc:contributor> <dc:creator>Meyer, Andrea H.</dc:creator> <dc:creator>Meinlschmidt, Gunther</dc:creator> <dcterms:title>Maternal adversities during pregnancy and cord blood oxytocin receptor (OXTR) DNA methylation</dcterms:title> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/44830/3/Unternaehrer_2-1a3s92ce6romm4.pdf"/> <dc:contributor>Unternaehrer, Eva</dc:contributor> <dc:contributor>Meyer, Andrea H.</dc:contributor> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/44830/3/Unternaehrer_2-1a3s92ce6romm4.pdf"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/43"/> <dc:contributor>Dempster, Emma</dc:contributor> <dc:creator>Hellhammer, Dirk H.</dc:creator> <dc:creator>Dempster, Emma</dc:creator> <dc:contributor>Hellhammer, Dirk H.</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-02-04T14:47:41Z</dcterms:available> <dcterms:abstract xml:lang="eng">The aim of this study was to investigate whether maternal adversities and cortisol levels during pregnancy predict cord blood DNA methylation of the oxytocin receptor (OXTR). We collected cord blood of 39 babies born to mothers participating in a cross-sectional study (N = 100) conducted in Basel, Switzerland (2007-10). Mothers completed the Inventory of Life Events (second trimester: T2), the Edinburgh Postnatal Depression Scale (EPDS, third trimester: T3), the Trier Inventory of Chronic Stress (TICS-K, 1-3 weeks postpartum) and provided saliva samples (T2, T3) for maternal cortisol profiles, as computed by the area under the curve with respect to ground (AUCg) or increase (AUCi) for the cortisol awakening response (CAR) and for diurnal cortisol profiles (DAY). OXTR DNA methylation was quantified using Sequenom EpiTYPER. The number of stressful life events (P = 0.032), EPDS score (P = 0.007) and cortisol AUCgs at T2 (CAR: P = 0.020; DAY: P = 0.024) were negatively associated with OXTR DNA methylation. Our findings suggest that distinct prenatal adversities predict decreased DNA methylation in a gene that is relevant for childbirth, maternal behavior and wellbeing of mother and offspring. If a reduced OXTR methylation increases OXTR expression, our findings could suggest an epigenetic adaptation to an adverse early environment.</dcterms:abstract> <dc:creator>Staehli, Simon</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/43"/> <dc:contributor>Bolten, Margarete</dc:contributor> <dc:creator>Nast, Irina</dc:creator> <dc:creator>Lieb, Roselind</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Bolten, Margarete</dc:creator> <dc:contributor>Lieb, Roselind</dc:contributor> </rdf:Description> </rdf:RDF>

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