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Mismatch negativity and cognitive performance in the course of schizophrenia

Mismatch negativity and cognitive performance in the course of schizophrenia

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HIRT, Vanessa, David SCHUBRING, Inga SCHALINSKI, Brigitte ROCKSTROH, 2019. Mismatch negativity and cognitive performance in the course of schizophrenia. In: International Journal of Psychophysiology. ISSN 0167-8760. eISSN 1872-7697. Available under: doi: 10.1016/j.ijpsycho.2019.01.006

@article{Hirt2019-01-23Misma-44769, title={Mismatch negativity and cognitive performance in the course of schizophrenia}, year={2019}, doi={10.1016/j.ijpsycho.2019.01.006}, issn={0167-8760}, journal={International Journal of Psychophysiology}, author={Hirt, Vanessa and Schubring, David and Schalinski, Inga and Rockstroh, Brigitte} }

eng Schubring, David Schalinski, Inga 2019-01-30T11:20:24Z Rockstroh, Brigitte 2019-01-30T11:20:24Z Background:<br />Cognitive deficits and abnormal event-related brain potentials (ERP) have been proposed as risk markers for the development of schizophrenia. Evidence is inconclusive whether these markers indicate a risk for the development of psychosis or illness progression.<br /><br />Methods:<br />The present study aimed at further clarification by comparing symptom expression (Brief Psychiatric Rating Scale, BRPS), the ERP Mismatch Negativity (MMN), and neuropsychological performance on the MATRICS Consensus Cognitive Battery between healthy controls (HC, n = 38) and individuals at different stages of illness: individuals at risk for psychosis (ARP, n = 33), patients at first admission, thus, early stage (ES, n = 35), chronic schizophrenia patients (CS, n = 25). Moreover, symptom expression was reassessed for ARP and ES at a 6 months follow-up.<br /><br />Results:<br />MMN was smaller in individuals with manifest psychosis (ES, CS) than in HC, but did not differ between ARP and HC. In contrast, ARP showed similar cognitive deficits as ES and CS, all three groups differing from HC. Lower cognitive performance predicted higher symptom severity at index assessments and 6 months follow-up in ARP and ES, while MMN did not explain additional variance.<br /><br />Conclusion:<br />MMN seems to mark manifest psychosis, independent of early or chronic stage, while cognitive deficits mark early present psychopathology in individuals at risk for and with diagnosed psychosis rather than illness progression. 2019-01-23 Rockstroh, Brigitte Hirt, Vanessa Schalinski, Inga Mismatch negativity and cognitive performance in the course of schizophrenia Hirt, Vanessa Schubring, David

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