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4'C-Ethynyl-thymidine acts as a chain terminator during DNA-synthesis catalyzed by HIV-1 reverse transcriptase

4'C-Ethynyl-thymidine acts as a chain terminator during DNA-synthesis catalyzed by HIV-1 reverse transcriptase

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Prüfsumme: MD5:73af3014a6587410fb12d09a6fa074d5

SUMMERER, Daniel, Andreas MARX, 2005. 4'C-Ethynyl-thymidine acts as a chain terminator during DNA-synthesis catalyzed by HIV-1 reverse transcriptase. In: Bioorganic & Medicinal Chemistry Letters. 15(4), pp. 869-871. ISSN 0960-894X. Available under: doi: 10.1016/j.bmcl.2004.12.072

@article{Summerer2005-02-154CEth-434, title={4'C-Ethynyl-thymidine acts as a chain terminator during DNA-synthesis catalyzed by HIV-1 reverse transcriptase}, year={2005}, doi={10.1016/j.bmcl.2004.12.072}, number={4}, volume={15}, issn={0960-894X}, journal={Bioorganic & Medicinal Chemistry Letters}, pages={869--871}, author={Summerer, Daniel and Marx, Andreas} }

Recently, 4'C-ethynyl nucleoside analogues have been identified as highly potent agents against HIV-1, including several multidrug-resistant strains. In contrast to most known nucleoside inhibitors 4'C-ethynyl nucleoside analogues possess a 3'-hydroxyl function. Here we show that the 5'O-triphosphate of 4'C-ethynyl thymidine gets readily incorporated into a nascent DNA strand by HIV-1 reverse transcriptase and significantly inhibits further post-incorporation chain extension by the enzyme. Marx, Andreas Marx, Andreas First publ. in: Bioorganic & medicinal chemistry letters 15 (2005), 4, pp. 869-871 Summerer, Daniel application/pdf 2011-07-01T10:08:56Z 4'C-Ethynyl-thymidine acts as a chain terminator during DNA-synthesis catalyzed by HIV-1 reverse transcriptase eng Summerer, Daniel 2011-07-01T10:08:56Z deposit-license 2005-02-15

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