KOPS - The Institutional Repository of the University of Konstanz

Induction of IL‐10‐balanced immune profiles following exposure to LTA from Staphylococcus epidermidis

Aufgrund von Vorbereitungen auf eine neue Version von KOPS, können kommenden Montag und Dienstag keine Publikationen eingereicht werden. (Due to preparations for a new version of KOPS, no publications can be submitted next Monday and Tuesday.)

Induction of IL‐10‐balanced immune profiles following exposure to LTA from Staphylococcus epidermidis

Cite This

Files in this item

Files Size Format View

There are no files associated with this item.

VOLZ, Thomas, Susanne KAESLER, Christian DRAING, Thomas HARTUNG, Martin RÖCKEN, Yuliya SKABYTSKA, Tilo BIEDERMANN, 2018. Induction of IL‐10‐balanced immune profiles following exposure to LTA from Staphylococcus epidermidis. In: Experimental Dermatology. 27(4), pp. 318-326. ISSN 0906-6705. eISSN 1600-0625. Available under: doi: 10.1111/exd.13540

@article{Volz2018-04Induc-43385, title={Induction of IL‐10‐balanced immune profiles following exposure to LTA from Staphylococcus epidermidis}, year={2018}, doi={10.1111/exd.13540}, number={4}, volume={27}, issn={0906-6705}, journal={Experimental Dermatology}, pages={318--326}, author={Volz, Thomas and Kaesler, Susanne and Draing, Christian and Hartung, Thomas and Röcken, Martin and Skabytska, Yuliya and Biedermann, Tilo} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/43385"> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/43385"/> <dc:creator>Draing, Christian</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-09-26T13:51:56Z</dcterms:available> <dc:creator>Kaesler, Susanne</dc:creator> <dc:language>eng</dc:language> <dc:creator>Volz, Thomas</dc:creator> <dc:contributor>Skabytska, Yuliya</dc:contributor> <dc:creator>Röcken, Martin</dc:creator> <dc:contributor>Biedermann, Tilo</dc:contributor> <dc:creator>Biedermann, Tilo</dc:creator> <dcterms:title>Induction of IL‐10‐balanced immune profiles following exposure to LTA from Staphylococcus epidermidis</dcterms:title> <dc:contributor>Draing, Christian</dc:contributor> <dc:creator>Hartung, Thomas</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Volz, Thomas</dc:contributor> <dcterms:abstract xml:lang="eng">Staphylococcus epidermidis colonises human skin without apparent inflammation, but a dominance of S. epidermidis and S. aureus is characteristic of cutaneous microbial dysbiosis in atopic dermatitis (AD). While S. aureus can trigger AD, the role of S. epidermidis is less understood. We characterised consequences of innate immune sensing of lipoteichoic acid (LTA) preparations derived from S. epidermidis (epi‐LTA) or S. aureus (aureus‐LTA). Therefore, dendritic cell (DC) activation and consecutive priming of antigen‐specific T cells following exposure of DC to epi‐LTA or aureus‐LTA were investigated. Mimicking acute AD, exposure of DC to IL‐4 and LTAs was analysed. Exposure to epi‐LTA or aureus‐LTA activated human immune cells and murine dendritic cells (DCs) via TLR2/MyD88, however, resulting in divergent immune profiles. Differences between LTAs were significant for IL‐6, IL‐12p40 and IL‐12p70 but not for IL‐10, which was best reflected by the IL‐12p70‐to‐IL‐10 ratio being IL‐10‐balanced for epi‐LTA but pro‐inflammatory for aureus‐LTA. LTA‐exposed DCs activated CD4+ T cells; however, while T‐cell‐derived IL‐10 was equivalent between LTAs, IFN‐γ and IL‐17 were significantly higher for aureus‐LTA. Mimicking acute AD by exposing DCs to IL‐4 and LTAs revealed that IL‐4 significantly and uniformly suppressed epi‐LTA‐induced cytokine production, keeping the IL‐12p70‐to‐IL‐10 ratio balanced. In contrast, exposure of DCs to aureus‐LTA and IL‐4 enhanced IL‐12p70 but suppressed IL‐10 levels, further unbalancing the IL‐12p70‐to‐IL‐10 ratio. These data demonstrate opposing immune consequences following exposure to staphylococcal LTAs. Epi‐LTA induced IL‐10‐balanced, aureus‐LTA pro‐inflammatory immune profiles.</dcterms:abstract> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Skabytska, Yuliya</dc:creator> <dc:contributor>Kaesler, Susanne</dc:contributor> <dc:contributor>Röcken, Martin</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-09-26T13:51:56Z</dc:date> <dcterms:issued>2018-04</dcterms:issued> <dc:contributor>Hartung, Thomas</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> </rdf:Description> </rdf:RDF>

This item appears in the following Collection(s)

Search KOPS


Browse

My Account