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Prolonged Intake of Dietary Lipids Alters Membrane Structure and T Cell Responses in LDLr<sup>-/-</sup> Mice

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Prolonged Intake of Dietary Lipids Alters Membrane Structure and T Cell Responses in LDLr-/- Mice

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POLLOCK, Abigail H., Nicodemus TEDLA, Sarah E. HANCOCK, Rhea CORNELY, Todd W. MITCHELL, Zhengmin YANG, Maaike KOCKX, Robert G. PARTON, Jérémie ROSSY, Katharina GAUS, 2016. Prolonged Intake of Dietary Lipids Alters Membrane Structure and T Cell Responses in LDLr-/- Mice. In: The Journal of Immunology. 196(10), pp. 3993-4002. ISSN 0022-1767. eISSN 1550-6606. Available under: doi: 10.4049/jimmunol.1501261

@article{Pollock2016Prolo-43040, title={Prolonged Intake of Dietary Lipids Alters Membrane Structure and T Cell Responses in LDLr-/- Mice}, year={2016}, doi={10.4049/jimmunol.1501261}, number={10}, volume={196}, issn={0022-1767}, journal={The Journal of Immunology}, pages={3993--4002}, author={Pollock, Abigail H. and Tedla, Nicodemus and Hancock, Sarah E. and Cornely, Rhea and Mitchell, Todd W. and Yang, Zhengmin and Kockx, Maaike and Parton, Robert G. and Rossy, Jérémie and Gaus, Katharina} }

Cornely, Rhea Rossy, Jérémie Prolonged Intake of Dietary Lipids Alters Membrane Structure and T Cell Responses in LDLr<sup>-/-</sup> Mice Pollock, Abigail H. Pollock, Abigail H. Parton, Robert G. 2018-08-09T09:27:05Z Tedla, Nicodemus Tedla, Nicodemus Parton, Robert G. eng Yang, Zhengmin Kockx, Maaike Yang, Zhengmin Mitchell, Todd W. 2018-08-09T09:27:05Z Cornely, Rhea Hancock, Sarah E. Mitchell, Todd W. Although it is recognized that lipids and membrane organization in T cells affect signaling and T cell activation, to what extent dietary lipids alter T cell responsiveness in the absence of obesity and inflammation is not known. In this study, we fed low-density lipoprotein receptor knockout mice a Western high-fat diet for 1 or 9 wk and examined T cell responses in vivo along with T cell lipid composition, membrane order, and activation ex vivo. Our data showed that high levels of circulating lipids for a prolonged period elevated CD4<sup>+</sup> and CD8<sup>+</sup> T cell proliferation and resulted in an increased proportion of CD4<sup>+</sup> central-memory T cells within the draining lymph nodes following induction of contact hypersensitivity. In addition, the 9-wk Western high-fat diet elevated the total phospholipid content and monounsaturated fatty acid level, but decreased saturated phosphatidylcholine and sphingomyelin within the T cells. The altered lipid composition in the circulation, and of T cells, was also reflected by enhanced membrane order at the activation site of ex vivo activated T cells that corresponded to increased IL-2 mRNA levels. In conclusion, dietary lipids can modulate T cell lipid composition and responses in lipoprotein receptor knockout mice even in the absence of excess weight gain and a proinflammatory environment. Rossy, Jérémie Hancock, Sarah E. Kockx, Maaike Gaus, Katharina Gaus, Katharina 2016

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