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The role of norepinephrine and alpha-adrenergic receptors in acute stress-induced changes in granulocytes and monocytes

The role of norepinephrine and alpha-adrenergic receptors in acute stress-induced changes in granulocytes and monocytes

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BEIS, Daniel, Roland VON KÄNEL, Nadja HEIMGARTNER, Claudia ZUCCARELLA-HACKL, Alexander BÜRKLE, Ulrike EHLERT, Petra H. WIRTZ, 2018. The role of norepinephrine and alpha-adrenergic receptors in acute stress-induced changes in granulocytes and monocytes. In: Psychosomatic medicine. 80(7), pp. 649-658. ISSN 0033-3174. eISSN 1534-7796. Available under: doi: 10.1097/PSY.0000000000000620

@article{Beis2018-09norep-42868, title={The role of norepinephrine and alpha-adrenergic receptors in acute stress-induced changes in granulocytes and monocytes}, year={2018}, doi={10.1097/PSY.0000000000000620}, number={7}, volume={80}, issn={0033-3174}, journal={Psychosomatic medicine}, pages={649--658}, author={Beis, Daniel and von Känel, Roland and Heimgartner, Nadja and Zuccarella-Hackl, Claudia and Bürkle, Alexander and Ehlert, Ulrike and Wirtz, Petra H.} }

Wirtz, Petra H. 2018-09 Beis, Daniel 2018-07-17T11:04:06Z Bürkle, Alexander Beis, Daniel Zuccarella-Hackl, Claudia Objective Acute stress induces redistribution of circulating leucocytes in humans. Whereas effects on lymphocytes as adaptive immune cells are well-understood, the mechanisms underlying stress effects on granulocytes and monocytes as innate immune blood cells are still elusive. We investigated whether the stress hormone norepinephrine (NE) and α-adrenergic receptors (α-ADRs) may play a mediating role.<br />Methods In a stress study, we cross-sectionally tested in 44 healthy men for associations between stress-induced NE increases and simultaneous granulocyte and monocyte cell count increases, as measured immediately before and several times after the Trier Social Stress Test. In a subsequent infusion study, 21 healthy men participated in three different experimental trials with sequential infusions of 1 and 15-min duration with varying substances [saline as placebo, the non-specific α-ADR blocker phentolamine (2.5mg/min), and NE (5μg/min)]: trial1=saline+saline, trial2=saline+NE, trial3=phentolamine+NE. Granulocyte and monocyte cell numbers were assessed before, immediately after, 10min, and 30min after infusion procedures.<br />Results In the stress study, higher NE related to higher neutrophil stress changes (β=.31,p=.045, R2change=.09), but not epinephrine stress changes. In the infusion study, saline+NE induced significant increases in neutrophil (F(3/60)=43.50,p<.001,η<sup>2</sup>=.69) and monocyte (F(3/60)=18.56,p<.001,η sup>2</sup>=.48) numbers compared to saline+saline. With phentolamine+NE, neutrophil (F(3/60)=14.41,p<.001,η<sup>2</sup>=.42) and monocyte counts (F(2.23/44.6)=4.32,p=.016,η<sup>2</sup>=.18) remained increased compared to saline+saline but were lower compared to saline+NE (neutrophils: F(3/60)=19.55,p<.001,η <sup>2</sup>=.494, monocytes: F(3/60)=2.54,p=.065,η<sup>2</sup>=.11) indicating partial mediation by α-ADRs. Trials did not differ in eosinophil and basophil count reactivity.<br />Conclusions Our findings suggest that NE-induced immediate increases in neutrophil and monocyte numbers resemble psychosocial stress effects and can be reduced by blockade of α-ADRs. Ehlert, Ulrike eng Heimgartner, Nadja 2018-07-17T11:04:06Z von Känel, Roland Ehlert, Ulrike terms-of-use von Känel, Roland Heimgartner, Nadja Zuccarella-Hackl, Claudia The role of norepinephrine and alpha-adrenergic receptors in acute stress-induced changes in granulocytes and monocytes Bürkle, Alexander Wirtz, Petra H.

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