Protein-DNA interactions at the simian virus 40 origin of replication

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BAUR, Claus-Peter, Kay KLAUSING, Martin SCHEFFNER, Hans STAHL, Rolf KNIPPERS, 1988. Protein-DNA interactions at the simian virus 40 origin of replication. In: Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 951(2-3), pp. 388-395. ISSN 0167-4781. eISSN 1879-2634. Available under: doi: 10.1016/0167-4781(88)90111-X

@article{Baur1988Prote-42778, title={Protein-DNA interactions at the simian virus 40 origin of replication}, year={1988}, doi={10.1016/0167-4781(88)90111-X}, number={2-3}, volume={951}, issn={0167-4781}, journal={Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression}, pages={388--395}, author={Baur, Claus-Peter and Klausing, Kay and Scheffner, Martin and Stahl, Hans and Knippers, Rolf} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dcterms:title>Protein-DNA interactions at the simian virus 40 origin of replication</dcterms:title> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:issued>1988</dcterms:issued> <dc:date rdf:datatype="">2018-07-04T16:33:12Z</dc:date> <dc:creator>Scheffner, Martin</dc:creator> <dc:contributor>Scheffner, Martin</dc:contributor> <dc:contributor>Baur, Claus-Peter</dc:contributor> <dc:creator>Klausing, Kay</dc:creator> <dc:creator>Knippers, Rolf</dc:creator> <dcterms:abstract xml:lang="eng">Simian Virus 40 (SV40)-encoded large T antigen has an intrinsic ATP-dependent DNA-unwinding activity which is necessary for an early step in the activation of the viral origin of replication. Isolated T antigen unwinds any double-stranded DNA, regardless of whether it is linear or circularly closed. However, initiation of DNA replication depends on an intact origin of replication, and even minor deviations from the wild-type origin sequence abolish the template activity of an origin-bearing plasmid. This discrepancy suggests that T antigen may not be sufficient for origin activation and that other, probably cellular, functions are involved. We have isolated a cellular protein, the LOB protein, which specifically interacts with the AT-rich region of the SV40 origin and which induces a pronounced bending of the bound DNA.</dcterms:abstract> <dcterms:available rdf:datatype="">2018-07-04T16:33:12Z</dcterms:available> <dc:language>eng</dc:language> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <bibo:uri rdf:resource=""/> <dc:contributor>Stahl, Hans</dc:contributor> <dc:contributor>Knippers, Rolf</dc:contributor> <dc:creator>Stahl, Hans</dc:creator> <dspace:isPartOfCollection rdf:resource=""/> <dc:contributor>Klausing, Kay</dc:contributor> <dc:creator>Baur, Claus-Peter</dc:creator> <dcterms:isPartOf rdf:resource=""/> </rdf:Description> </rdf:RDF>

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