RNA helicase activity associated with the human p68 protein

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HIRLING, Harald, Martin SCHEFFNER, Tobias RESTLE, Hans STAHL, 1989. RNA helicase activity associated with the human p68 protein. In: Nature. 339, pp. 562-564. ISSN 0028-0836. eISSN 1476-4687. Available under: doi: 10.1038/339562a0

@article{Hirling1989helic-42775, title={RNA helicase activity associated with the human p68 protein}, year={1989}, doi={10.1038/339562a0}, volume={339}, issn={0028-0836}, journal={Nature}, pages={562--564}, author={Hirling, Harald and Scheffner, Martin and Restle, Tobias and Stahl, Hans} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/42775"> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-07-04T16:27:32Z</dcterms:available> <dc:creator>Hirling, Harald</dc:creator> <dc:contributor>Hirling, Harald</dc:contributor> <dcterms:issued>1989</dcterms:issued> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:title>RNA helicase activity associated with the human p68 protein</dcterms:title> <dc:creator>Restle, Tobias</dc:creator> <dc:creator>Stahl, Hans</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Restle, Tobias</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-07-04T16:27:32Z</dc:date> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:language>eng</dc:language> <dc:contributor>Stahl, Hans</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:abstract xml:lang="eng">It has been proposed that p68, a nuclear protein of relative molecular mass 68,000, functions in the regulation of cell growth and division. A complementary DNA analysis of the protein has revealed extensive amino-acid sequence homology to the products of a set of genes recently identified in organisms as diverse as Escherichia coli and man, which include the eukaryotic translation initiation factor elF-4A. The protein products of the new gene family have several motifs in common which are thought to be involved in nucleic acid unwinding. As yet, however, only elF-4A, through its effect on RNA, has been shown to possess unwinding activity. Here we report that purified p68 also exhibits RNA-dependent ATPase activity and functions as an RNA helicase in vitro. The protein was first identified by its specific immunological cross reaction with the simian virus 40 large T antigen, the transforming protein of a small DNA tumour virus. Surprisingly, T antigen also has an RNA-unwinding activity: the homology between the two polypeptides, although confined to only a small region resembling the epitope of the cross-reacting antibody (PAb204), should therefore be of functional significance. Furthermore, the RNA-unwinding activity may be involved in the growth-regulating functions of both proteins.</dcterms:abstract> <dc:contributor>Scheffner, Martin</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/42775"/> <dc:creator>Scheffner, Martin</dc:creator> </rdf:Description> </rdf:RDF>

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