Type of Publication: | Journal article |
Publication status: | Published |
Author: | Zubel, Tabea; Bürkle, Alexander; Mangerich, Aswin |
Year of publication: | 2018 |
Published in: | Toxicology Letters ; 293 (2018). - pp. 21-30. - ISSN 0378-4274. - eISSN 1879-3169 |
Pubmed ID: | 29277573 |
DOI (citable link): | https://dx.doi.org/10.1016/j.toxlet.2017.12.014 |
Summary: |
The bi-functional chemical warfare agent sulfur mustard (SM), whose release in asymmetric conflicts or terrorist attacks represents a realistic threat, induces several kinds of biomolecular adducts, including highly toxic DNA adducts. Isotope dilution liquid chromatographic tandem mass spectrometry (ID-LC-MS/MS) is considered the gold standard for highly accurate, precise, specific and sensitive quantification of DNA adducts in general. Recently, a number of LC-MS/MS approaches have been established to analyze SM-induced protein and DNA adducts in cell culture and rodent animal models. As DNA adducts are mechanism-based biomarkers for SM exposure, results from such studies provide a deeper understanding of the etiology of SM-induced pathologies, especially of long-term effects such as cancer formation. As a result, medical treatment of SM-exposed individuals might be improved. Yet, despite the progress that has been made during the last years, there is still a need for advanced methods of ID-LC-MS/MS for the detection and quantitation of SM adducts.
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Subject (DDC): | 570 Biosciences, Biology |
Keywords: | Sulfur mustard, DNA damage, LC-MS/MS, Mass spectrometry, Biomarkers, Chemical warfare agents, Technical review |
Bibliography of Konstanz: | Yes |
Refereed: | Yes |
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ZUBEL, Tabea, Alexander BÜRKLE, Aswin MANGERICH, 2018. Mass spectrometric analysis of sulfur mustard-induced biomolecular adducts : Are DNA adducts suitable biomarkers of exposure?. In: Toxicology Letters. 293, pp. 21-30. ISSN 0378-4274. eISSN 1879-3169. Available under: doi: 10.1016/j.toxlet.2017.12.014
@article{Zubel2018-09-01spect-42546, title={Mass spectrometric analysis of sulfur mustard-induced biomolecular adducts : Are DNA adducts suitable biomarkers of exposure?}, year={2018}, doi={10.1016/j.toxlet.2017.12.014}, volume={293}, issn={0378-4274}, journal={Toxicology Letters}, pages={21--30}, author={Zubel, Tabea and Bürkle, Alexander and Mangerich, Aswin} }
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