Antagonistic PCP Signaling Pathways in the developing Drosophila eye

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KATANAEV, Vladimir L., Diane EGGER-ADAM, Andrew TOMLINSON, 2018. Antagonistic PCP Signaling Pathways in the developing Drosophila eye. In: Scientific reports. 8(1), 5741. eISSN 2045-2322. Available under: doi: 10.1038/s41598-018-24053-3

@article{Katanaev2018-04-10Antag-42296, title={Antagonistic PCP Signaling Pathways in the developing Drosophila eye}, year={2018}, doi={10.1038/s41598-018-24053-3}, number={1}, volume={8}, journal={Scientific reports}, author={Katanaev, Vladimir L. and Egger-Adam, Diane and Tomlinson, Andrew}, note={Article Number: 5741} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dcterms:isPartOf rdf:resource=""/> <dspace:isPartOfCollection rdf:resource=""/> <dspace:hasBitstream rdf:resource=""/> <dc:contributor>Egger-Adam, Diane</dc:contributor> <dc:creator>Egger-Adam, Diane</dc:creator> <dcterms:abstract xml:lang="eng">In Planar cell polarity (PCP), cells coordinately polarize their cytoskeletons within the plane of the epithelium in which they lie. In most insect epithelia this is indicated by the coordinated projections of the hairs secreted by the ectodermal cells. PCP of this form has been effectively studied in Drosophila, but it has proven difficult to achieve an integrated description of the roles played by the various proteins. In the insect eye, PCP is not evident as the polarization of individual cells, but as the asymmetric arrangements of the cells of the ommatidia. This different form of PCP allows different studies to be performed, and using this system we have detected the action of two antagonistic signaling pathways. Even though antagonistic, the two pathways synergize and cooperate to ensure that the correct arrangement of the cells is achieved. The cooperative use of antagonistic signaling pathways occurs in the polarization of chemotacting cells, and we discuss the possibility that a similar molecular principle may underlie PCP.</dcterms:abstract> <dc:date rdf:datatype="">2018-05-11T08:31:04Z</dc:date> <dcterms:rights rdf:resource=""/> <dc:creator>Katanaev, Vladimir L.</dc:creator> <dc:rights>terms-of-use</dc:rights> <dcterms:issued>2018-04-10</dcterms:issued> <bibo:uri rdf:resource=""/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:available rdf:datatype="">2018-05-11T08:31:04Z</dcterms:available> <dc:language>eng</dc:language> <dc:creator>Tomlinson, Andrew</dc:creator> <dc:contributor>Katanaev, Vladimir L.</dc:contributor> <dc:contributor>Tomlinson, Andrew</dc:contributor> <dcterms:title>Antagonistic PCP Signaling Pathways in the developing Drosophila eye</dcterms:title> <dcterms:hasPart rdf:resource=""/> </rdf:Description> </rdf:RDF>

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