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A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter

A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter

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BRÈS, Vanessa, Rosemary E KIERNAN, Laetitia K. LINARES, Christine CHABLE-BESSIA, Olga PLECHAKOVA, Céline TRÉAND, Stephane EMILIANI, Jean-Marie PELOPONESE, Martin SCHEFFNER, Monsef BENKIRANE, 2003. A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter. In: Nature cell biology. 5(8), pp. 754-761. ISSN 1465-7392. eISSN 1476-4679. Available under: doi: 10.1038/ncb1023

@article{Bres2003-08nonpr-42225, title={A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter}, year={2003}, doi={10.1038/ncb1023}, number={8}, volume={5}, issn={1465-7392}, journal={Nature cell biology}, pages={754--761}, author={Brès, Vanessa and Kiernan, Rosemary E and Linares, Laetitia K. and Chable-Bessia, Christine and Plechakova, Olga and Tréand, Céline and Emiliani, Stephane and Peloponese, Jean-Marie and Scheffner, Martin and Benkirane, Monsef} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/42225"> <dc:contributor>Scheffner, Martin</dc:contributor> <dc:contributor>Chable-Bessia, Christine</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-05-02T08:02:23Z</dcterms:available> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-05-02T08:02:23Z</dc:date> <dc:contributor>Benkirane, Monsef</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Tréand, Céline</dc:contributor> <dc:creator>Kiernan, Rosemary E</dc:creator> <dc:creator>Plechakova, Olga</dc:creator> <dc:creator>Linares, Laetitia K.</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Peloponese, Jean-Marie</dc:creator> <dcterms:abstract xml:lang="eng">The human immunodeficiency virus type 1 (HIV-1) encodes a potent transactivator, Tat, which functions through binding to a short leader RNA, called transactivation responsive element (TAR). Recent studies suggest that Tat activates the HIV-1 long terminal repeat (LTR), mainly by adapting co-activator complexes, such as p300, PCAF and the positive transcription elongation factor P-TEFb, to the promoter. Here, we show that the proto-oncoprotein Hdm2 interacts with Tat and mediates its ubiquitination in vitro and in vivo. In addition, Hdm2 is a positive regulator of Tat-mediated transactivation, indicating that the transcriptional properties of Tat are stimulated by ubiquitination. Fusion of ubiquitin to Tat bypasses the requirement of Hdm2 for efficient transactivation, supporting the notion that ubiquitin has a non-proteolytic function in Tat-mediated transactivation.</dcterms:abstract> <dc:contributor>Kiernan, Rosemary E</dc:contributor> <dc:creator>Brès, Vanessa</dc:creator> <dc:creator>Chable-Bessia, Christine</dc:creator> <dc:creator>Emiliani, Stephane</dc:creator> <dc:contributor>Linares, Laetitia K.</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Tréand, Céline</dc:creator> <dc:contributor>Peloponese, Jean-Marie</dc:contributor> <dc:creator>Benkirane, Monsef</dc:creator> <dc:creator>Scheffner, Martin</dc:creator> <dcterms:title>A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter</dcterms:title> <dc:language>eng</dc:language> <dcterms:issued>2003-08</dcterms:issued> <dc:contributor>Emiliani, Stephane</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/42225"/> <dc:contributor>Plechakova, Olga</dc:contributor> <dc:contributor>Brès, Vanessa</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> </rdf:Description> </rdf:RDF>

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