Probability metrics to calibrate stochastic chemical kinetics

Zitieren

Dateien zu dieser Ressource

Dateien Größe Format Anzeige

Zu diesem Dokument gibt es keine Dateien.

KOEPPL, Heinz, Gianluca SETTI, Serge PELET, Mauro MANGIA, Tatjana PETROV, Matthias PETER, 2010. Probability metrics to calibrate stochastic chemical kinetics. 2010 IEEE International Symposium on Circuits and Systems - ISCAS 2010. Paris, France, 30. Mai 2010 - 2. Jun 2010. In: Proceedings of 2010 IEEE International Symposium on Circuits and Systems : Paris, France : 30 May - 2 June 2010. Piscataway, NJ:IEEE, pp. 541-544. ISBN 978-1-4244-5308-5. Available under: doi: 10.1109/ISCAS.2010.5537549

@inproceedings{Koeppl2010Proba-42221, title={Probability metrics to calibrate stochastic chemical kinetics}, year={2010}, doi={10.1109/ISCAS.2010.5537549}, isbn={978-1-4244-5308-5}, address={Piscataway, NJ}, publisher={IEEE}, booktitle={Proceedings of 2010 IEEE International Symposium on Circuits and Systems : Paris, France : 30 May - 2 June 2010}, pages={541--544}, author={Koeppl, Heinz and Setti, Gianluca and Pelet, Serge and Mangia, Mauro and Petrov, Tatjana and Peter, Matthias} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/42221"> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-05-02T07:39:29Z</dc:date> <dc:contributor>Pelet, Serge</dc:contributor> <dc:contributor>Petrov, Tatjana</dc:contributor> <dc:language>eng</dc:language> <dc:creator>Koeppl, Heinz</dc:creator> <dc:contributor>Mangia, Mauro</dc:contributor> <dc:contributor>Setti, Gianluca</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-05-02T07:39:29Z</dcterms:available> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/36"/> <dc:contributor>Peter, Matthias</dc:contributor> <dc:creator>Pelet, Serge</dc:creator> <dc:creator>Setti, Gianluca</dc:creator> <dc:creator>Petrov, Tatjana</dc:creator> <dc:creator>Peter, Matthias</dc:creator> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/42221"/> <dcterms:issued>2010</dcterms:issued> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:title>Probability metrics to calibrate stochastic chemical kinetics</dcterms:title> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/36"/> <dc:contributor>Koeppl, Heinz</dc:contributor> <dcterms:abstract xml:lang="eng">Calibration or model parameter estimation from measured data is an ubiquitous problem in engineering. In systems biology this problem turns out to be particularly challenging due to very short data-records, low signal-to-noise ratio of data acquisition, large intrinsic process noise and limited measurement access to only a few, of sometimes several hundreds, state variables. We review state-of-the-art model calibration techniques and also discuss their relation to the general reverse-engineering problem in systems biology. For biomolecular circuits involving low-copy-number molecules we adopt a Markov process setup and discuss a calibration approach based on suitable metrics between probability measures and propose the metrics computation for the multivariate case. In particular, we use Kantorovich's distance and devise an algorithm, for the case when FACS (fluorescence-activated cell sorting) measurements are given. We discuss a case study involving FACS data for the high-osmolarity glycerol (HOG) pathway in budding yeast.</dcterms:abstract> <dc:creator>Mangia, Mauro</dc:creator> </rdf:Description> </rdf:RDF>

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto