KOPS - Das Institutionelle Repositorium der Universität Konstanz

Topography for Independent Binding of α-Helical and PPII-Helical Ligands to a Peroxisomal SH3 Domain

Topography for Independent Binding of α-Helical and PPII-Helical Ligands to a Peroxisomal SH3 Domain

Zitieren

Dateien zu dieser Ressource

Dateien Größe Format Anzeige

Zu diesem Dokument gibt es keine Dateien.

DOUANGAMATH, Alice, Fabian V FILIPP, André T.J KLEIN, Phil BARNETT, Peijian ZOU, Tineke VOORN-BROUWER, M.Cristina VEGA, Olga M. MAYANS, Michael SATTLER, Ben DISTEL, 2002. Topography for Independent Binding of α-Helical and PPII-Helical Ligands to a Peroxisomal SH3 Domain. In: Molecular Cell. 10(5), pp. 1007-1017. ISSN 1097-2765. eISSN 1097-4164. Available under: doi: 10.1016/S1097-2765(02)00749-9

@article{Douangamath2002Topog-42089, title={Topography for Independent Binding of α-Helical and PPII-Helical Ligands to a Peroxisomal SH3 Domain}, year={2002}, doi={10.1016/S1097-2765(02)00749-9}, number={5}, volume={10}, issn={1097-2765}, journal={Molecular Cell}, pages={1007--1017}, author={Douangamath, Alice and Filipp, Fabian V and Klein, André T.J and Barnett, Phil and Zou, Peijian and Voorn-Brouwer, Tineke and Vega, M.Cristina and Mayans, Olga M. and Sattler, Michael and Distel, Ben} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/42089"> <dc:contributor>Distel, Ben</dc:contributor> <dc:contributor>Sattler, Michael</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Sattler, Michael</dc:creator> <dc:contributor>Voorn-Brouwer, Tineke</dc:contributor> <dc:contributor>Barnett, Phil</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/42089"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-04-18T10:19:28Z</dc:date> <dc:creator>Klein, André T.J</dc:creator> <dc:language>eng</dc:language> <dc:creator>Filipp, Fabian V</dc:creator> <dc:contributor>Filipp, Fabian V</dc:contributor> <dc:creator>Voorn-Brouwer, Tineke</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Mayans, Olga M.</dc:creator> <dc:contributor>Zou, Peijian</dc:contributor> <dc:creator>Barnett, Phil</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Klein, André T.J</dc:contributor> <dc:creator>Zou, Peijian</dc:creator> <dcterms:abstract xml:lang="eng">While the function of most small signaling domains is confined to binary ligand interactions, the peroxisomal Pex13p SH3 domain has the unique capacity of binding to two different ligands, Pex5p and Pex14p. We have used this domain as a model to decipher its structurally independent ligand binding sites. By the combined use of X-ray crystallography, NMR spectroscopy, and circular dichroism, we show that the two ligands bind in unrelated conformations to patches located at opposite surfaces of this SH3 domain. Mutations in the Pex13p SH3 domain that abolish interactions within the Pex13p-Pex5p interface specifically impair PTS1-dependent protein import into yeast peroxisomes.</dcterms:abstract> <dc:creator>Douangamath, Alice</dc:creator> <dc:contributor>Vega, M.Cristina</dc:contributor> <dcterms:title>Topography for Independent Binding of α-Helical and PPII-Helical Ligands to a Peroxisomal SH3 Domain</dcterms:title> <dc:contributor>Douangamath, Alice</dc:contributor> <dc:creator>Vega, M.Cristina</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-04-18T10:19:28Z</dcterms:available> <dcterms:issued>2002</dcterms:issued> <dc:creator>Distel, Ben</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Mayans, Olga M.</dc:contributor> </rdf:Description> </rdf:RDF>

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto