New insights in chemokine signaling

Cite This

Files in this item

Checksum: MD5:b0b6ad8a6659a41e8d8092eb723e4dee

LEGLER, Daniel F., Marcus THELEN, 2018. New insights in chemokine signaling. In: F1000Research. 7, 95. eISSN 2046-1402. Available under: doi: 10.12688/f1000research.13130.1

@article{Legler2018insig-41931, title={New insights in chemokine signaling}, year={2018}, doi={10.12688/f1000research.13130.1}, volume={7}, journal={F1000Research}, author={Legler, Daniel F. and Thelen, Marcus}, note={Article Number: 95} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/41931"> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/41931/1/Legler_2-ar1459h6msq68.pdf"/> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/41931"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Legler, Daniel F.</dc:contributor> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/41931/1/Legler_2-ar1459h6msq68.pdf"/> <dcterms:abstract xml:lang="eng">Chemokine signaling is essential for coordinated cell migration in health and disease to specifically govern cell positioning in space and time. Typically, chemokines signal through heptahelical, G protein-coupled receptors to orchestrate cell migration. Notably, chemokine receptors are highly dynamic structures and signaling efficiency largely depends on the discrete contact with the ligand. Promiscuity of both chemokines and chemokine receptors, combined with biased signaling and allosteric modulation of receptor activation, guarantees a tightly controlled recruitment and positioning of individual cells within the local environment at a given time. Here, we discuss recent insights in understanding chemokine gradient formation by atypical chemokine receptors and how typical chemokine receptors can transmit distinct signals to translate guidance cues into coordinated cell locomotion in space and time.</dcterms:abstract> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-04-03T11:15:39Z</dcterms:available> <dc:rights>terms-of-use</dc:rights> <dc:contributor>Thelen, Marcus</dc:contributor> <dc:language>eng</dc:language> <dc:creator>Legler, Daniel F.</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-04-03T11:15:39Z</dc:date> <dc:creator>Thelen, Marcus</dc:creator> <dcterms:issued>2018</dcterms:issued> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:title>New insights in chemokine signaling</dcterms:title> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> </rdf:Description> </rdf:RDF>

Downloads since Apr 3, 2018 (Information about access statistics)

Legler_2-ar1459h6msq68.pdf 99

This item appears in the following Collection(s)

Search KOPS


Browse

My Account