Site-specific PEGylation of proteins containing unnatural amino acids

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DEITERS, Alexander, T. Ashton CROPP, Daniel SUMMERER, Mridul MUKHERJI, Peter G. SCHULTZ, 2004. Site-specific PEGylation of proteins containing unnatural amino acids. In: Bioorganic & Medicinal Chemistry Letters. 14(23), pp. 5743-5745. ISSN 0960-894X. Available under: doi: 10.1016/j.bmcl.2004.09.059

@article{Deiters2004-12-06Sites-419, title={Site-specific PEGylation of proteins containing unnatural amino acids}, year={2004}, doi={10.1016/j.bmcl.2004.09.059}, number={23}, volume={14}, issn={0960-894X}, journal={Bioorganic & Medicinal Chemistry Letters}, pages={5743--5745}, author={Deiters, Alexander and Cropp, T. Ashton and Summerer, Daniel and Mukherji, Mridul and Schultz, Peter G.} }

application/pdf Schultz, Peter G. Cropp, T. Ashton Bioorganic & medicinal chemistry letters ; 14 (2004), 23. - S. 5743-5745 Mukherji, Mridul Here, we report a generally applicable PEGylation methodology based on the site-specific incorporation of para-azidophenylalanine into proteins in yeast. The azido group was used in a mild [3+2] cycloaddition reaction with an alkyne derivatized PEG reagent to afford selectively PEGylated protein. This strategy should be useful for the generation of selectively PEGylated proteins for therapeutic applications. Deiters, Alexander Cropp, T. Ashton 2004-12-06 2011-07-01T13:09:46Z Deiters, Alexander Summerer, Daniel eng deposit-license Site-specific PEGylation of proteins containing unnatural amino acids Mukherji, Mridul Schultz, Peter G. 2011-07-01T13:09:46Z Summerer, Daniel

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