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Outcome in patients converting to psychosis following a treated clinical high risk state

Outcome in patients converting to psychosis following a treated clinical high risk state

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MALLA, Ashok, Marianne DE BONNEVILLE, Jai SHAH, Gerald JORDAN, Marita PRUESSNER, Kia FARIDI, Mark RABINOVITCH, Srividya N. IYER, Ridha JOOBER, 2018. Outcome in patients converting to psychosis following a treated clinical high risk state. In: Early Intervention in Psychiatry. 12(4), pp. 715-719. ISSN 1751-7885. eISSN 1751-7893. Available under: doi: 10.1111/eip.12431

@article{Malla2018-08Outco-41411, title={Outcome in patients converting to psychosis following a treated clinical high risk state}, year={2018}, doi={10.1111/eip.12431}, number={4}, volume={12}, issn={1751-7885}, journal={Early Intervention in Psychiatry}, pages={715--719}, author={Malla, Ashok and de Bonneville, Marianne and Shah, Jai and Jordan, Gerald and Pruessner, Marita and Faridi, Kia and Rabinovitch, Mark and Iyer, Srividya N. and Joober, Ridha} }

Jordan, Gerald Joober, Ridha Outcome in patients converting to psychosis following a treated clinical high risk state 2018-08 Iyer, Srividya N. Faridi, Kia Joober, Ridha Malla, Ashok Iyer, Srividya N. de Bonneville, Marianne Faridi, Kia Malla, Ashok Rabinovitch, Mark eng Aim<br />We explored 2-year outcomes in a sample of clinical high risk (CHR) patients who converted to psychosis despite receiving interventions.<br /><br />Methods<br />Of 167 CHR patients, 18 had converted to psychosis and received treatment for their first episode of psychosis in an early intervention service over 2 years.<br /><br />Results<br />Compared to patients admitted directly to the same early intervention service without having been identified as CHR prior to onset of psychosis, CHR converters were in remission for fewer months (M = 5 vs M = 10); were more likely to be prescribed more than 1 antipsychotic medication (90% vs 68%) and to receive clozapine treatment (38% vs 2%) over 2 years.<br /><br />Conclusions<br />CHR patients who convert to psychosis may be inherently more resistant to comprehensive treatment and may have poorer outcomes. Conversion to psychosis from a state of CHR can be reduced to a rate of 10%–12% following interventions, yet outcomes for patients who convert despite such interventions remain unexplored. Shah, Jai Rabinovitch, Mark Pruessner, Marita Jordan, Gerald Shah, Jai 2018-02-19T07:45:37Z de Bonneville, Marianne Pruessner, Marita 2018-02-19T07:45:37Z

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