Type of Publication: | Journal article |
Publication status: | Published |
Author: | Heck, Angela; Milnik, Annette; Vukojevic, Vanja; Petrovska, Jana; Egli, Tobias; Singer, Jochen; Escobar, Pablo; Kolassa, Iris-Tatjana; Elbert, Thomas; Papassotiropoulos, Andreas et al. |
Year of publication: | 2017 |
Published in: | Nature Human Behaviour ; 1 (2017), 4. - 0081. - eISSN 2397-3374 |
DOI (citable link): | https://dx.doi.org/10.1038/s41562-017-0081 |
Summary: |
Many mental disorders represent the extremes of the normal distribution of traits, which are related to multiple cognitive and emotional dimensions. By performing whole-exome sequencing of healthy, young subjects with extremely high versus extremely low aversive memory performance, we identified TROVE2 as a gene implicated in emotional memory in health and disease. TROVE2 encodes Ro60, a broadly expressed RNA-binding protein implicated in the regulation of inflammatory gene expression and autoimmunity. A regulatory TROVE2 variant was linked to higher emotional memory capacity and higher emotional memory-related brain activation in healthy subjects. In addition, TROVE2 was associated with traumatic memory and the frequency of post-traumatic stress disorder in genocide survivors.
|
Subject (DDC): | 150 Psychology |
Bibliography of Konstanz: | Yes |
Files | Size | Format | View |
---|---|---|---|
There are no files associated with this item. |
HECK, Angela, Annette MILNIK, Vanja VUKOJEVIC, Jana PETROVSKA, Tobias EGLI, Jochen SINGER, Pablo ESCOBAR, Iris-Tatjana KOLASSA, Thomas ELBERT, Andreas PAPASSOTIROPOULOS, 2017. Exome sequencing of healthy phenotypic extremes links TROVE2 to emotional memory and PTSD. In: Nature Human Behaviour. 1(4), 0081. eISSN 2397-3374. Available under: doi: 10.1038/s41562-017-0081
@article{Heck2017-03-27Exome-41290, title={Exome sequencing of healthy phenotypic extremes links TROVE2 to emotional memory and PTSD}, year={2017}, doi={10.1038/s41562-017-0081}, number={4}, volume={1}, journal={Nature Human Behaviour}, author={Heck, Angela and Milnik, Annette and Vukojevic, Vanja and Petrovska, Jana and Egli, Tobias and Singer, Jochen and Escobar, Pablo and Kolassa, Iris-Tatjana and Elbert, Thomas and Papassotiropoulos, Andreas}, note={Article Number: 0081} }
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/41290"> <dc:contributor>Papassotiropoulos, Andreas</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/41290"/> <dc:creator>Escobar, Pablo</dc:creator> <dc:contributor>Elbert, Thomas</dc:contributor> <dc:contributor>Egli, Tobias</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-02-09T14:56:15Z</dcterms:available> <dc:contributor>Milnik, Annette</dc:contributor> <dc:creator>Heck, Angela</dc:creator> <dc:creator>Egli, Tobias</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-02-09T14:56:15Z</dc:date> <dc:contributor>Escobar, Pablo</dc:contributor> <dc:creator>Kolassa, Iris-Tatjana</dc:creator> <dc:contributor>Heck, Angela</dc:contributor> <dc:creator>Papassotiropoulos, Andreas</dc:creator> <dcterms:title>Exome sequencing of healthy phenotypic extremes links TROVE2 to emotional memory and PTSD</dcterms:title> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/43"/> <dc:contributor>Singer, Jochen</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/43"/> <dc:creator>Milnik, Annette</dc:creator> <dcterms:issued>2017-03-27</dcterms:issued> <dc:contributor>Kolassa, Iris-Tatjana</dc:contributor> <dc:creator>Petrovska, Jana</dc:creator> <dc:language>eng</dc:language> <dc:contributor>Vukojevic, Vanja</dc:contributor> <dc:creator>Elbert, Thomas</dc:creator> <dc:contributor>Petrovska, Jana</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:abstract xml:lang="eng">Many mental disorders represent the extremes of the normal distribution of traits, which are related to multiple cognitive and emotional dimensions. By performing whole-exome sequencing of healthy, young subjects with extremely high versus extremely low aversive memory performance, we identified TROVE2 as a gene implicated in emotional memory in health and disease. TROVE2 encodes Ro60, a broadly expressed RNA-binding protein implicated in the regulation of inflammatory gene expression and autoimmunity. A regulatory TROVE2 variant was linked to higher emotional memory capacity and higher emotional memory-related brain activation in healthy subjects. In addition, TROVE2 was associated with traumatic memory and the frequency of post-traumatic stress disorder in genocide survivors.</dcterms:abstract> <dc:creator>Singer, Jochen</dc:creator> <dc:creator>Vukojevic, Vanja</dc:creator> </rdf:Description> </rdf:RDF>