Exome sequencing of healthy phenotypic extremes links TROVE2 to emotional memory and PTSD
| Type of Publication: | Journal article |
| Publication status: | Published |
| Author: | Heck, Angela; Milnik, Annette; Vukojevic, Vanja; Petrovska, Jana; Egli, Tobias; Singer, Jochen; Escobar, Pablo; Kolassa, Iris-Tatjana; Elbert, Thomas; Papassotiropoulos, Andreas et al. |
| Year of publication: | 2017 |
| Published in: | Nature Human Behaviour ; 1 (2017), 4. - 0081. - eISSN 2397-3374 |
| DOI (citable link): | https://dx.doi.org/10.1038/s41562-017-0081 |
| Summary: |
Many mental disorders represent the extremes of the normal distribution of traits, which are related to multiple cognitive and emotional dimensions. By performing whole-exome sequencing of healthy, young subjects with extremely high versus extremely low aversive memory performance, we identified TROVE2 as a gene implicated in emotional memory in health and disease. TROVE2 encodes Ro60, a broadly expressed RNA-binding protein implicated in the regulation of inflammatory gene expression and autoimmunity. A regulatory TROVE2 variant was linked to higher emotional memory capacity and higher emotional memory-related brain activation in healthy subjects. In addition, TROVE2 was associated with traumatic memory and the frequency of post-traumatic stress disorder in genocide survivors.
|
| Subject (DDC): | 150 Psychology |
| Bibliography of Konstanz: | Yes |
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HECK, Angela, Annette MILNIK, Vanja VUKOJEVIC, Jana PETROVSKA, Tobias EGLI, Jochen SINGER, Pablo ESCOBAR, Iris-Tatjana KOLASSA, Thomas ELBERT, Andreas PAPASSOTIROPOULOS, 2017. Exome sequencing of healthy phenotypic extremes links TROVE2 to emotional memory and PTSD. In: Nature Human Behaviour. 1(4), 0081. eISSN 2397-3374. Available under: doi: 10.1038/s41562-017-0081
@article{Heck2017-03-27Exome-41290, title={Exome sequencing of healthy phenotypic extremes links TROVE2 to emotional memory and PTSD}, year={2017}, doi={10.1038/s41562-017-0081}, number={4}, volume={1}, journal={Nature Human Behaviour}, author={Heck, Angela and Milnik, Annette and Vukojevic, Vanja and Petrovska, Jana and Egli, Tobias and Singer, Jochen and Escobar, Pablo and Kolassa, Iris-Tatjana and Elbert, Thomas and Papassotiropoulos, Andreas}, note={Article Number: 0081} }
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