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Cortisol awakening response and hippocampal volume : vulnerability for major depressive disorder?

Cortisol awakening response and hippocampal volume : vulnerability for major depressive disorder?

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DEDOVIC, Katarina, Veronika ENGERT, Annie DUCHESNE, Sonja Damika LUE, Julie ANDREWS, Simona I. EFANOV, Thomas BEAUDRY, Jens C. PRUESSNER, 2010. Cortisol awakening response and hippocampal volume : vulnerability for major depressive disorder?. In: Biological Psychiatry. 68(9), pp. 847-853. ISSN 0006-3223. eISSN 1873-2402. Available under: doi: 10.1016/j.biopsych.2010.07.025

@article{Dedovic2010-11-01Corti-40929, title={Cortisol awakening response and hippocampal volume : vulnerability for major depressive disorder?}, year={2010}, doi={10.1016/j.biopsych.2010.07.025}, number={9}, volume={68}, issn={0006-3223}, journal={Biological Psychiatry}, pages={847--853}, author={Dedovic, Katarina and Engert, Veronika and Duchesne, Annie and Lue, Sonja Damika and Andrews, Julie and Efanov, Simona I. and Beaudry, Thomas and Pruessner, Jens C.} }

Dedovic, Katarina Andrews, Julie Andrews, Julie Dedovic, Katarina Engert, Veronika Beaudry, Thomas Lue, Sonja Damika Background<br /><br />Major depressive disorder is associated with dysregulated basal cortisol levels and small hippocampal (HC) volume. However, it is still debated whether these phenomena are a consequence of the illness or whether they may represent a vulnerability marker existing before the illness onset. Here, we aimed to examine this notion of vulnerability by assessing whether abnormalities in basal cortisol secretion and HC volumes are already present in a sample of healthy young adults who showed varying levels of depressive tendencies, but at subclinical levels.<br /><br />Methods<br /><br />We recruited healthy young men and women from the local university. On the basis of depression scores derived from standard questionnaires, three groups were formed: a control group (n = 27), a subclinical group (n = 23), and a high-risk subclinical group (n = 9). The participants underwent a magnetic resonance imaging scan and collected saliva samples for the assessment of diurnal cortisol levels.<br /><br />Results<br /><br />Both the subclinical and the high-risk subclinical group failed to show a significant increase in cortisol levels after awakening. The high-risk subclinical group also showed a lower area-under-the-curve increase of cortisol levels after awakening compared with control subjects. In addition, this group also had smaller total HC volume compared with control subjects.<br /><br />Conclusions<br /><br />The findings from this subclinical sample suggest that dysregulated cortisol awakening response and small HC volume may constitute vulnerability factors for major depressive disorder. Further investigations are needed to discern the mechanisms that may underlie these phenomena. 2010-11-01 2017-12-14T07:16:08Z Pruessner, Jens C. eng Duchesne, Annie 2017-12-14T07:16:08Z Efanov, Simona I. Cortisol awakening response and hippocampal volume : vulnerability for major depressive disorder? Duchesne, Annie Beaudry, Thomas Lue, Sonja Damika Engert, Veronika Pruessner, Jens C. Efanov, Simona I.

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