Type of Publication: | Journal article |
Publication status: | Published |
Author: | Bodnar, Michael; Malla, Ashok K.; Czechowska, Yvonne; Benoit, Audrey; Fathalli, Ferid; Joober, Ridha; Pruessner, Marita; Pruessner, Jens; Lepage, Martin |
Year of publication: | 2010 |
Published in: | Schizophrenia Research ; 122 (2010), 1-3. - pp. 72-80. - ISSN 0920-9964. - eISSN 1573-2509 |
Pubmed ID: | 20630708 |
DOI (citable link): | https://dx.doi.org/10.1016/j.schres.2010.06.013 |
Summary: |
Objektive
The temporolimbic region has been implicated in the pathophysiology in schizophrenia. More specifically, significantly smaller hippocampal volumes but not amygdala volumes have been identified at onset in first-episode schizophrenia (FES) patients. However, volumetric differences (namely, in the hippocampus) exhibit an ambiguous relationship with long-term outcome. So, we examined the relationship between hippocampus and amygdala volumes and early remission status. Methods We compared hippocampus and amygdala volumes between 40 non-remitted and 17 remitted FES patients and 57 healthy controls. Amygdala and hippocampus were manually traced with the hippocampus additionally segmented into three parts: body, head, and tail. Remission was defined as mild or less on both positive and negative symptoms over a period of 6 consecutive months as per the 2005 Remission in Schizophrenia Working Group criteria. Results A significant [group × structure × side] interaction revealed outcome groups differed in hippocampus tail volumes; significantly on the left (non-remitted = 694 ± 175 mm3; remitted = 855 ± 133 mm3; p = 0.001) with a trend difference on the right (non-remitted = 723 ± 162 mm3; remitted = 833 ± 126 mm3; p = 0.023). Groups did not differ in body, head, or amygdala volumes bi-laterally. Conclusions A smaller hippocampal tail volume may represent a neural marker in FES patients who do not achieve early remission after the first 6 months of treatment. The early identification of patients with poor outcome with respect to the hippocampus tail may encourage the search for new, more target-specific, medications in hope of improving outcome and moving us towards a better understanding of the pathophysiology of schizophrenia. |
Subject (DDC): | 150 Psychology |
Keywords: | First-episode schizophrenia; Hippocampus; Amygdala; Remission; Structural MRI; Neuroimaging |
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BODNAR, Michael, Ashok K. MALLA, Yvonne CZECHOWSKA, Audrey BENOIT, Ferid FATHALLI, Ridha JOOBER, Marita PRUESSNER, Jens PRUESSNER, Martin LEPAGE, 2010. Neural markers of remission in first-episode schizophrenia : A volumetric neuroimaging study of the hippocampus and amygdala. In: Schizophrenia Research. 122(1-3), pp. 72-80. ISSN 0920-9964. eISSN 1573-2509. Available under: doi: 10.1016/j.schres.2010.06.013
@article{Bodnar2010-09Neura-40927, title={Neural markers of remission in first-episode schizophrenia : A volumetric neuroimaging study of the hippocampus and amygdala}, year={2010}, doi={10.1016/j.schres.2010.06.013}, number={1-3}, volume={122}, issn={0920-9964}, journal={Schizophrenia Research}, pages={72--80}, author={Bodnar, Michael and Malla, Ashok K. and Czechowska, Yvonne and Benoit, Audrey and Fathalli, Ferid and Joober, Ridha and Pruessner, Marita and Pruessner, Jens and Lepage, Martin} }