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Neural markers of remission in first-episode schizophrenia : A volumetric neuroimaging study of the hippocampus and amygdala

Neural markers of remission in first-episode schizophrenia : A volumetric neuroimaging study of the hippocampus and amygdala

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BODNAR, Michael, Ashok K. MALLA, Yvonne CZECHOWSKA, Audrey BENOIT, Ferid FATHALLI, Ridha JOOBER, Marita PRUESSNER, Jens PRUESSNER, Martin LEPAGE, 2010. Neural markers of remission in first-episode schizophrenia : A volumetric neuroimaging study of the hippocampus and amygdala. In: Schizophrenia Research. 122(1-3), pp. 72-80. ISSN 0920-9964. eISSN 1573-2509. Available under: doi: 10.1016/j.schres.2010.06.013

@article{Bodnar2010-09Neura-40927, title={Neural markers of remission in first-episode schizophrenia : A volumetric neuroimaging study of the hippocampus and amygdala}, year={2010}, doi={10.1016/j.schres.2010.06.013}, number={1-3}, volume={122}, issn={0920-9964}, journal={Schizophrenia Research}, pages={72--80}, author={Bodnar, Michael and Malla, Ashok K. and Czechowska, Yvonne and Benoit, Audrey and Fathalli, Ferid and Joober, Ridha and Pruessner, Marita and Pruessner, Jens and Lepage, Martin} }

Malla, Ashok K. Malla, Ashok K. Pruessner, Jens Bodnar, Michael Lepage, Martin Joober, Ridha Benoit, Audrey Pruessner, Jens 2017-12-13T14:55:58Z eng 2010-09 Czechowska, Yvonne 2017-12-13T14:55:58Z Benoit, Audrey Lepage, Martin Fathalli, Ferid Pruessner, Marita Fathalli, Ferid Bodnar, Michael Neural markers of remission in first-episode schizophrenia : A volumetric neuroimaging study of the hippocampus and amygdala Joober, Ridha Objektive<br /><br />The temporolimbic region has been implicated in the pathophysiology in schizophrenia. More specifically, significantly smaller hippocampal volumes but not amygdala volumes have been identified at onset in first-episode schizophrenia (FES) patients. However, volumetric differences (namely, in the hippocampus) exhibit an ambiguous relationship with long-term outcome. So, we examined the relationship between hippocampus and amygdala volumes and early remission status.<br />Methods<br /><br />We compared hippocampus and amygdala volumes between 40 non-remitted and 17 remitted FES patients and 57 healthy controls. Amygdala and hippocampus were manually traced with the hippocampus additionally segmented into three parts: body, head, and tail. Remission was defined as mild or less on both positive and negative symptoms over a period of 6 consecutive months as per the 2005 Remission in Schizophrenia Working Group criteria.<br /><br />Results<br /><br />A significant [group × structure × side] interaction revealed outcome groups differed in hippocampus tail volumes; significantly on the left (non-remitted = 694 ± 175 mm<sup>3</sup>; remitted = 855 ± 133 mm<sup>3</sup>; p = 0.001) with a trend difference on the right (non-remitted = 723 ± 162 mm<sup>3</sup>; remitted = 833 ± 126 mm<sup>3</sup>; p = 0.023). Groups did not differ in body, head, or amygdala volumes bi-laterally.<br /><br />Conclusions<br /><br />A smaller hippocampal tail volume may represent a neural marker in FES patients who do not achieve early remission after the first 6 months of treatment. The early identification of patients with poor outcome with respect to the hippocampus tail may encourage the search for new, more target-specific, medications in hope of improving outcome and moving us towards a better understanding of the pathophysiology of schizophrenia. Pruessner, Marita Czechowska, Yvonne

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