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Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase

Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase

Type of Publication: Journal article
Publication status: Published
URI (citable link): http://nbn-resolving.de/urn:nbn:de:bsz:352-2-emplm7zacqca1
Author: Betz, Karin; Nilforoushan, Arman; Wyss, Laura A.; Diederichs, Kay; Sturla, Shana J.; Marx, Andreas
Year of publication: 2017
Published in: Chemical Communications : ChemComm ; 53 (2017), 94. - pp. 12704-12707. - ISSN 1359-7345. - eISSN 1364-548X
Pubmed ID: 29136072
DOI (citable link): https://dx.doi.org/10.1039/c7cc07173f
Summary:
The possibility to sequence cytotoxic O6-alkylG DNA adducts would greatly benefit research. Recently we reported a benzimidazole-derived nucleotide that is selectively incorporated opposite the damaged site by a mutated DNA polymerase. Here we provide the structural basis for this reaction which may spur future developments in DNA damage sequencing.
Subject (DDC): 540 Chemistry
Link to License: Terms of use
Bibliography of Konstanz: Yes

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BETZ, Karin, Arman NILFOROUSHAN, Laura A. WYSS, Kay DIEDERICHS, Shana J. STURLA, Andreas MARX, 2017. Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase. In: Chemical Communications : ChemComm. 53(94), pp. 12704-12707. ISSN 1359-7345. eISSN 1364-548X. Available under: doi: 10.1039/c7cc07173f

@article{Betz2017-11-23Struc-40878, title={Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase}, year={2017}, doi={10.1039/c7cc07173f}, number={94}, volume={53}, issn={1359-7345}, journal={Chemical Communications : ChemComm}, pages={12704--12707}, author={Betz, Karin and Nilforoushan, Arman and Wyss, Laura A. and Diederichs, Kay and Sturla, Shana J. and Marx, Andreas} }

Wyss, Laura A. 2017-12-08T13:20:12Z Betz, Karin Marx, Andreas Betz, Karin 2017-12-08T13:20:12Z Sturla, Shana J. Diederichs, Kay Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase Nilforoushan, Arman Marx, Andreas terms-of-use Sturla, Shana J. Wyss, Laura A. Nilforoushan, Arman 2017-11-23 The possibility to sequence cytotoxic O<sup>6</sup>-alkylG DNA adducts would greatly benefit research. Recently we reported a benzimidazole-derived nucleotide that is selectively incorporated opposite the damaged site by a mutated DNA polymerase. Here we provide the structural basis for this reaction which may spur future developments in DNA damage sequencing. Diederichs, Kay eng

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