Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase

Betz, Karin; Nilforoushan, Arman; Wyss, Laura A.; Diederichs, Kay; Sturla, Shana J.; Marx, Andreas

Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase

Files

Betz_2-emplm7zacqca1.pdf(195.17 KB)

Date

2017

Authors

Betz, Karin

Nilforoushan, Arman

Wyss, Laura A.

Diederichs, Kay

Sturla, Shana J.

Marx, Andreas

Publication type

Journal article

Publication status

Published

Published in

Chemical Communications : ChemComm ; 53 (2017), 94. - pp. 12704-12707. - ISSN 1359-7345. - eISSN 1364-548X

Abstract

The possibility to sequence cytotoxic O⁶-alkylG DNA adducts would greatly benefit research. Recently we reported a benzimidazole-derived nucleotide that is selectively incorporated opposite the damaged site by a mutated DNA polymerase. Here we provide the structural basis for this reaction which may spur future developments in DNA damage sequencing.

Subject (DDC)

540 Chemistry

Cite This

ISO 690

BETZ, Karin, Arman NILFOROUSHAN, Laura A. WYSS, Kay DIEDERICHS, Shana J. STURLA, Andreas MARX, 2017. Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase. In: Chemical Communications : ChemComm. 53(94), pp. 12704-12707. ISSN 1359-7345. eISSN 1364-548X. Available under: doi: 10.1039/c7cc07173f

BibTex

@article{Betz2017-11-23Struc-40878,
  year={2017},
  doi={10.1039/c7cc07173f},
  title={Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase},
  number={94},
  volume={53},
  issn={1359-7345},
  journal={Chemical Communications : ChemComm},
  pages={12704--12707},
  author={Betz, Karin and Nilforoushan, Arman and Wyss, Laura A. and Diederichs, Kay and Sturla, Shana J. and Marx, Andreas}
}

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Bibliography of Konstanz

Yes