KOPS - Das Institutionelle Repositorium der Universität Konstanz

Apoptosis in the Dorsal Lateral Geniculate Nucleus after Monocular Deprivation Involves Glutamate Signaling, NO Production, and PARP Activation

Apoptosis in the Dorsal Lateral Geniculate Nucleus after Monocular Deprivation Involves Glutamate Signaling, NO Production, and PARP Activation

Zitieren

Dateien zu dieser Ressource

Prüfsumme: MD5:1f71d7b65bbbf69902d66a3734332348

NUCCI, Carlo, Silvia PICCIRILLI, Paola RODINÒ, Robert NISTICÒ, Marina GRANDINETTI, Luciano CERULLI, Marcel LEIST, Pierluigi NICOTERA, Giacinto BAGETTA, 2000. Apoptosis in the Dorsal Lateral Geniculate Nucleus after Monocular Deprivation Involves Glutamate Signaling, NO Production, and PARP Activation. In: Biochemical and Biophysical Research Communications. 278(2), pp. 360-367. ISSN 0006-291X. eISSN 1090-2104. Available under: doi: 10.1006/bbrc.2000.3811

@article{Nucci2000-11-19Apopt-40835, title={Apoptosis in the Dorsal Lateral Geniculate Nucleus after Monocular Deprivation Involves Glutamate Signaling, NO Production, and PARP Activation}, year={2000}, doi={10.1006/bbrc.2000.3811}, number={2}, volume={278}, issn={0006-291X}, journal={Biochemical and Biophysical Research Communications}, pages={360--367}, author={Nucci, Carlo and Piccirilli, Silvia and Rodinò, Paola and Nisticò, Robert and Grandinetti, Marina and Cerulli, Luciano and Leist, Marcel and Nicotera, Pierluigi and Bagetta, Giacinto} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/40835"> <dc:contributor>Piccirilli, Silvia</dc:contributor> <dc:contributor>Bagetta, Giacinto</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Nisticò, Robert</dc:creator> <dcterms:issued>2000-11-19</dcterms:issued> <dc:contributor>Rodinò, Paola</dc:contributor> <dc:creator>Leist, Marcel</dc:creator> <dcterms:title>Apoptosis in the Dorsal Lateral Geniculate Nucleus after Monocular Deprivation Involves Glutamate Signaling, NO Production, and PARP Activation</dcterms:title> <dc:creator>Rodinò, Paola</dc:creator> <dc:contributor>Cerulli, Luciano</dc:contributor> <dc:creator>Bagetta, Giacinto</dc:creator> <dcterms:abstract xml:lang="eng">In mammals, visual experience during early postnatal life is critical for normal development of the visual system. Here we report that monocular deprivation for 2, 7, and 14 consecutive days causes p53 accumulation, cell death, and progressive loss of neurones in the dorsal lateral geniculate nucleus (dLGN) of newborn rats and these are prevented by NMDA and non-NMDA glutamate receptor antagonists, and by L-NAME, an inhibitor of nitric oxide synthesis. Monocular deprivation also increases dLGN levels of citrulline, the coproduct of nitric oxide synthesis, and this, as well as cell death and neuronal loss, is abolished by antagonists of glutamate receptors and by L-NAME. Finally, poly-(ADP-ribose) polymerase (PARP) knock-out mice appear to be protected from monocular deprivation-induced cell death. In conclusion, during early postnatal development of the rat visual system monocular deprivation causes excitotoxic, nitric oxide-mediated, cell death in the dLGN that appears to be apoptotic and also requires activation of PARP.</dcterms:abstract> <dc:creator>Nicotera, Pierluigi</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-12-05T10:15:25Z</dcterms:available> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/40835"/> <dc:contributor>Grandinetti, Marina</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:language>eng</dc:language> <dc:creator>Grandinetti, Marina</dc:creator> <dcterms:rights rdf:resource="https://kops.uni-konstanz.de/page/termsofuse"/> <dc:contributor>Nicotera, Pierluigi</dc:contributor> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/40835/1/Nucci_2-1pqefdn9j8wrr1.pdf"/> <dc:creator>Nucci, Carlo</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-12-05T10:15:25Z</dc:date> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Leist, Marcel</dc:contributor> <dc:creator>Piccirilli, Silvia</dc:creator> <dc:contributor>Nisticò, Robert</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Nucci, Carlo</dc:contributor> <dc:creator>Cerulli, Luciano</dc:creator> <dc:rights>terms-of-use</dc:rights> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/40835/1/Nucci_2-1pqefdn9j8wrr1.pdf"/> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 05.12.2017 (Informationen über die Zugriffsstatistik)

Nucci_2-1pqefdn9j8wrr1.pdf 8

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto