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Anatomy and behavioral function of serotonin receptors in Drosophila melanogaster larvae

Anatomy and behavioral function of serotonin receptors in Drosophila melanogaster larvae

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HUSER, Annina, Melanie ESCHMENT, Nazli GÜLLÜ, Katharina A.N. COLLINS, Kathrin BÖPPLE, Lyubov PANKEVYCH, Emilia ROLSING, Andreas S. THUM, 2017. Anatomy and behavioral function of serotonin receptors in Drosophila melanogaster larvae. In: PloS one. 12(8), e0181865. eISSN 1932-6203. Available under: doi: 10.1371/journal.pone.0181865

@article{Huser2017Anato-40440, title={Anatomy and behavioral function of serotonin receptors in Drosophila melanogaster larvae}, year={2017}, doi={10.1371/journal.pone.0181865}, number={8}, volume={12}, journal={PloS one}, author={Huser, Annina and Eschment, Melanie and Güllü, Nazli and Collins, Katharina A.N. and Böpple, Kathrin and Pankevych, Lyubov and Rolsing, Emilia and Thum, Andreas S.}, note={Article Number: e0181865} }

Pankevych, Lyubov Güllü, Nazli Anatomy and behavioral function of serotonin receptors in Drosophila melanogaster larvae eng Rolsing, Emilia Thum, Andreas S. Eschment, Melanie 2017-10-27T11:48:09Z Huser, Annina Huser, Annina Eschment, Melanie Böpple, Kathrin 2017 Thum, Andreas S. Güllü, Nazli Pankevych, Lyubov Böpple, Kathrin 2017-10-27T11:48:09Z The biogenic amine serotonin (5-HT) is an important neuroactive molecule in the central nervous system of the majority of animal phyla. 5-HT binds to specific G protein-coupled and ligand-gated ion receptors to regulate particular aspects of animal behavior. In Drosophila, as in many other insects this includes the regulation of locomotion and feeding. Due to its genetic amenability and neuronal simplicity the Drosophila larva has turned into a useful model for studying the anatomical and molecular basis of chemosensory behaviors. This is particularly true for the olfactory system, which is mostly described down to the synaptic level over the first three orders of neuronal information processing. Here we focus on the 5-HT receptor system of the Drosophila larva. In a bipartite approach consisting of anatomical and behavioral experiments we describe the distribution and the implications of individual 5-HT receptors on naïve and acquired chemosensory behaviors. Our data suggest that 5-HT<sub>1A</sub>, 5-HT<sub>1B</sub>, and 5-HT<sub>7</sub> are dispensable for larval naïve olfactory and gustatory choice behaviors as well as for appetitive and aversive associative olfactory learning and memory. In contrast, we show that 5-HT/5-HT<sub>2A</sub> signaling throughout development, but not as an acute neuronal function, affects associative olfactory learning and memory using high salt concentration as a negative unconditioned stimulus. These findings describe for the first time an involvement of 5-HT signaling in learning and memory in Drosophila larvae. In the longer run these results may uncover developmental, 5-HT dependent principles related to reinforcement processing possibly shared with adult Drosophila and other insects. Collins, Katharina A.N. Rolsing, Emilia Collins, Katharina A.N.

Dateiabrufe seit 27.10.2017 (Informationen über die Zugriffsstatistik)

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