@article{Schury2017-12Alter-40330,
  year={2017},
  doi={10.1186/s12888-017-1367-2},
  title={Alterations of hair cortisol and dehydroepiandrosterone in mother-infant-dyads with maternal childhood maltreatment},
  number={1},
  volume={17},
  journal={BMC Psychiatry},
  author={Schury, Katharina and Koenig, Alexandra M. and Isele, Dorothea and Hulbert, A. L. and Krause, Sabrina and Umlauft, Maria and Kolassa, Stephan and Ziegenhain, Ute and Karabatsiakis, Alexander and Kolassa, Iris-Tatjana},
  note={Article Number: 213}
}

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    <dc:rights>Attribution 4.0 International</dc:rights>
    <dc:creator>Umlauft, Maria</dc:creator>
    <dc:contributor>Koenig, Alexandra M.</dc:contributor>
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    <dc:contributor>Isele, Dorothea</dc:contributor>
    <dc:creator>Isele, Dorothea</dc:creator>
    <dc:contributor>Kolassa, Stephan</dc:contributor>
    <dc:creator>Kolassa, Iris-Tatjana</dc:creator>
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    <dcterms:abstract xml:lang="eng">Background&lt;br /&gt;Child maltreatment (CM) has severe effects on psychological and physical health. The hypothalamic-pituitary-adrenal (HPA) axis, the major stress system of the body, is dysregulated after CM. The analysis of cortisol and dehydroepiandrosterone (DHEA) in scalp hair presents a new and promising methodological approach to assess chronic HPA axis activity. This study investigated the effects of CM on HPA axis activity in the last trimester of pregnancy by measuring the two important signaling molecules, cortisol and DHEA in hair, shortly after parturition. In addition, we explored potential effects of maternal CM on her offspring’s endocrine milieu during pregnancy by measuring cortisol and DHEA in newborns’ hair.&lt;br /&gt;&lt;br /&gt;Methods&lt;br /&gt;CM was assessed with the Childhood Trauma Questionnaire (CTQ). Cortisol and DHEA were measured in hair samples of 94 mothers and 30 newborns, collected within six days after delivery. Associations of maternal CM on her own and her newborn’s cortisol as well as DHEA concentrations in hair were analyzed with heteroscedastic regression models.&lt;br /&gt;&lt;br /&gt;Results&lt;br /&gt;Higher CM was associated with significantly higher DHEA levels, but not cortisol concentrations in maternal hair. Moreover, maternal CM was positively, but only as a non-significant trend, associated with higher DHEA levels in the newborns’ hair.&lt;br /&gt;&lt;br /&gt;Conclusions&lt;br /&gt;Results suggest that the steroid milieu of the mother, at least on the level of DHEA, is altered after CM, possibly leading to non-genomic transgenerational effects on the developing fetus in utero. Indeed, we observed on an explorative level first hints that the endocrine milieu for the developing child might be altered in CM mothers. These results need extension and replication in future studies. The measurement of hair steroids in mothers and their newborns is promising, but more research is needed to better understand the effects of a maternal history of CM on the developing fetus.</dcterms:abstract>
    <dc:contributor>Ziegenhain, Ute</dc:contributor>
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    <dc:contributor>Umlauft, Maria</dc:contributor>
    <dc:contributor>Krause, Sabrina</dc:contributor>
    <dcterms:issued>2017-12</dcterms:issued>
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    <dc:creator>Hulbert, A. L.</dc:creator>
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    <dc:contributor>Hulbert, A. L.</dc:contributor>
    <dc:contributor>Kolassa, Iris-Tatjana</dc:contributor>
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    <dc:creator>Ziegenhain, Ute</dc:creator>
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    <dc:contributor>Schury, Katharina</dc:contributor>
    <dc:creator>Schury, Katharina</dc:creator>
    <dc:creator>Karabatsiakis, Alexander</dc:creator>
    <dc:creator>Kolassa, Stephan</dc:creator>
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    <dc:creator>Koenig, Alexandra M.</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-10-13T11:15:07Z</dc:date>
    <dc:language>eng</dc:language>
    <dcterms:title>Alterations of hair cortisol and dehydroepiandrosterone in mother-infant-dyads with maternal childhood maltreatment</dcterms:title>
    <dc:contributor>Karabatsiakis, Alexander</dc:contributor>
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