Alterations of hair cortisol and dehydroepiandrosterone in mother-infant-dyads with maternal childhood maltreatment

Thumbnail Image
Date
2017
Authors
Schury, Katharina
Koenig, Alexandra M.
Hulbert, A. L.
Krause, Sabrina
Umlauft, Maria
Kolassa, Stephan
Ziegenhain, Ute
Karabatsiakis, Alexander
Editors
Contact
Journal ISSN
Electronic ISSN
ISBN
Bibliographical data
Publisher
Series
DOI (citable link)
ArXiv-ID
International patent number
Link to the license
EU project number
Project
Open Access publication
Collections
Restricted until
Title in another language
Research Projects
Organizational Units
Journal Issue
Publication type
Journal article
Publication status
Published
Published in
BMC Psychiatry ; 17 (2017), 1. - 213. - eISSN 1471-244X
Abstract
Background
Child maltreatment (CM) has severe effects on psychological and physical health. The hypothalamic-pituitary-adrenal (HPA) axis, the major stress system of the body, is dysregulated after CM. The analysis of cortisol and dehydroepiandrosterone (DHEA) in scalp hair presents a new and promising methodological approach to assess chronic HPA axis activity. This study investigated the effects of CM on HPA axis activity in the last trimester of pregnancy by measuring the two important signaling molecules, cortisol and DHEA in hair, shortly after parturition. In addition, we explored potential effects of maternal CM on her offspring’s endocrine milieu during pregnancy by measuring cortisol and DHEA in newborns’ hair.

Methods
CM was assessed with the Childhood Trauma Questionnaire (CTQ). Cortisol and DHEA were measured in hair samples of 94 mothers and 30 newborns, collected within six days after delivery. Associations of maternal CM on her own and her newborn’s cortisol as well as DHEA concentrations in hair were analyzed with heteroscedastic regression models.

Results
Higher CM was associated with significantly higher DHEA levels, but not cortisol concentrations in maternal hair. Moreover, maternal CM was positively, but only as a non-significant trend, associated with higher DHEA levels in the newborns’ hair.

Conclusions
Results suggest that the steroid milieu of the mother, at least on the level of DHEA, is altered after CM, possibly leading to non-genomic transgenerational effects on the developing fetus in utero. Indeed, we observed on an explorative level first hints that the endocrine milieu for the developing child might be altered in CM mothers. These results need extension and replication in future studies. The measurement of hair steroids in mothers and their newborns is promising, but more research is needed to better understand the effects of a maternal history of CM on the developing fetus.
Summary in another language
Subject (DDC)
150 Psychology
Keywords
Cortisol, DHEA, Hair, Childhood maltreatment, Pregnancy, Transgenerational
Conference
Review
undefined / . - undefined, undefined. - (undefined; undefined)
Cite This
ISO 690SCHURY, Katharina, Alexandra M. KOENIG, Dorothea ISELE, A. L. HULBERT, Sabrina KRAUSE, Maria UMLAUFT, Stephan KOLASSA, Ute ZIEGENHAIN, Alexander KARABATSIAKIS, Iris-Tatjana KOLASSA, 2017. Alterations of hair cortisol and dehydroepiandrosterone in mother-infant-dyads with maternal childhood maltreatment. In: BMC Psychiatry. 17(1), 213. eISSN 1471-244X. Available under: doi: 10.1186/s12888-017-1367-2
BibTex
@article{Schury2017-12Alter-40330,
  year={2017},
  doi={10.1186/s12888-017-1367-2},
  title={Alterations of hair cortisol and dehydroepiandrosterone in mother-infant-dyads with maternal childhood maltreatment},
  number={1},
  volume={17},
  journal={BMC Psychiatry},
  author={Schury, Katharina and Koenig, Alexandra M. and Isele, Dorothea and Hulbert, A. L. and Krause, Sabrina and Umlauft, Maria and Kolassa, Stephan and Ziegenhain, Ute and Karabatsiakis, Alexander and Kolassa, Iris-Tatjana},
  note={Article Number: 213}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/40330">
    <dc:rights>Attribution 4.0 International</dc:rights>
    <dc:creator>Umlauft, Maria</dc:creator>
    <dc:contributor>Koenig, Alexandra M.</dc:contributor>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/40330/1/Schury_1-c078170d0414458f6.pdf"/>
    <dc:contributor>Isele, Dorothea</dc:contributor>
    <dc:creator>Isele, Dorothea</dc:creator>
    <dc:contributor>Kolassa, Stephan</dc:contributor>
    <dc:creator>Kolassa, Iris-Tatjana</dc:creator>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/4.0/"/>
    <dcterms:abstract xml:lang="eng">Background&lt;br /&gt;Child maltreatment (CM) has severe effects on psychological and physical health. The hypothalamic-pituitary-adrenal (HPA) axis, the major stress system of the body, is dysregulated after CM. The analysis of cortisol and dehydroepiandrosterone (DHEA) in scalp hair presents a new and promising methodological approach to assess chronic HPA axis activity. This study investigated the effects of CM on HPA axis activity in the last trimester of pregnancy by measuring the two important signaling molecules, cortisol and DHEA in hair, shortly after parturition. In addition, we explored potential effects of maternal CM on her offspring’s endocrine milieu during pregnancy by measuring cortisol and DHEA in newborns’ hair.&lt;br /&gt;&lt;br /&gt;Methods&lt;br /&gt;CM was assessed with the Childhood Trauma Questionnaire (CTQ). Cortisol and DHEA were measured in hair samples of 94 mothers and 30 newborns, collected within six days after delivery. Associations of maternal CM on her own and her newborn’s cortisol as well as DHEA concentrations in hair were analyzed with heteroscedastic regression models.&lt;br /&gt;&lt;br /&gt;Results&lt;br /&gt;Higher CM was associated with significantly higher DHEA levels, but not cortisol concentrations in maternal hair. Moreover, maternal CM was positively, but only as a non-significant trend, associated with higher DHEA levels in the newborns’ hair.&lt;br /&gt;&lt;br /&gt;Conclusions&lt;br /&gt;Results suggest that the steroid milieu of the mother, at least on the level of DHEA, is altered after CM, possibly leading to non-genomic transgenerational effects on the developing fetus in utero. Indeed, we observed on an explorative level first hints that the endocrine milieu for the developing child might be altered in CM mothers. These results need extension and replication in future studies. The measurement of hair steroids in mothers and their newborns is promising, but more research is needed to better understand the effects of a maternal history of CM on the developing fetus.</dcterms:abstract>
    <dc:contributor>Ziegenhain, Ute</dc:contributor>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/40330/1/Schury_1-c078170d0414458f6.pdf"/>
    <dc:contributor>Umlauft, Maria</dc:contributor>
    <dc:contributor>Krause, Sabrina</dc:contributor>
    <dcterms:issued>2017-12</dcterms:issued>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-10-13T11:15:07Z</dcterms:available>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:creator>Hulbert, A. L.</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/40330"/>
    <dc:contributor>Hulbert, A. L.</dc:contributor>
    <dc:contributor>Kolassa, Iris-Tatjana</dc:contributor>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <dc:creator>Ziegenhain, Ute</dc:creator>
    <dc:creator>Krause, Sabrina</dc:creator>
    <dc:contributor>Schury, Katharina</dc:contributor>
    <dc:creator>Schury, Katharina</dc:creator>
    <dc:creator>Karabatsiakis, Alexander</dc:creator>
    <dc:creator>Kolassa, Stephan</dc:creator>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:creator>Koenig, Alexandra M.</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-10-13T11:15:07Z</dc:date>
    <dc:language>eng</dc:language>
    <dcterms:title>Alterations of hair cortisol and dehydroepiandrosterone in mother-infant-dyads with maternal childhood maltreatment</dcterms:title>
    <dc:contributor>Karabatsiakis, Alexander</dc:contributor>
  </rdf:Description>
</rdf:RDF>
Internal note
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Contact
URL of original publication
Test date of URL
Examination date of dissertation
Method of financing
Comment on publication
Alliance license
Corresponding Authors der Uni Konstanz vorhanden
International Co-Authors
Bibliography of Konstanz
No
Refereed