Separation of Racemate from Excess Enantiomer of Chiral Nonracemic Compounds via Density Gradient Ultracentrifugation
| Publikationstyp: | Zeitschriftenartikel |
| Publikationsstatus: | Published |
| Autor/innen: | Mastai, Yitzhak; Völkel, Antje; Cölfen, Helmut |
| Erscheinungsjahr: | 2008 |
| Erschienen in: | Journal of the American Chemical Society : JACS ; 130 (2008), 8. - S. 2426-2427. - ISSN 0002-7863. - eISSN 1520-5126 |
| Pubmed ID: | 18254622 |
| DOI (zitierfähiger Link): | https://dx.doi.org/10.1021/ja067905i |
| Zusammenfassung: |
In this study, it is shown that preparative density gradient ultracentrifugation can be applied to separate racemate crystals from excess enantiomer crystals. This was demonstrated for alanine crystals separated in a 50 wt % Nycodenz gradient. The recovery rates of the pure enantiomers from the mixtures were good (70−90%), and the separation method showed accuracy in the third digit of the density. As such density differences between racemate and enantiomers can be found for a wide range of crystalline chiral compounds, the presented separation method should be applicable to a large variety of substances on a preparative scale.
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| Fachgebiet (DDC): | 540 Chemie |
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MASTAI, Yitzhak, Antje VÖLKEL, Helmut CÖLFEN, 2008. Separation of Racemate from Excess Enantiomer of Chiral Nonracemic Compounds via Density Gradient Ultracentrifugation. In: Journal of the American Chemical Society : JACS. 130(8), pp. 2426-2427. ISSN 0002-7863. eISSN 1520-5126. Available under: doi: 10.1021/ja067905i
@article{Mastai2008-02Separ-40113, title={Separation of Racemate from Excess Enantiomer of Chiral Nonracemic Compounds via Density Gradient Ultracentrifugation}, year={2008}, doi={10.1021/ja067905i}, number={8}, volume={130}, issn={0002-7863}, journal={Journal of the American Chemical Society : JACS}, pages={2426--2427}, author={Mastai, Yitzhak and Völkel, Antje and Cölfen, Helmut} }
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