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Higher body mass index (BMI) relates to lower glucocorticoid inhibition of inflammatory cytokine production following acute psychosocial stress in men

Higher body mass index (BMI) relates to lower glucocorticoid inhibition of inflammatory cytokine production following acute psychosocial stress in men

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WIRTZ, Petra H., 2015. Higher body mass index (BMI) relates to lower glucocorticoid inhibition of inflammatory cytokine production following acute psychosocial stress in men. In: Journal of Psychosomatic Research. 78(6), pp. 632. ISSN 0022-3999. eISSN 1879-1360. Available under: doi: 10.1016/j.jpsychores.2015.03.142

@article{Wirtz2015-06Highe-39800, title={Higher body mass index (BMI) relates to lower glucocorticoid inhibition of inflammatory cytokine production following acute psychosocial stress in men}, year={2015}, doi={10.1016/j.jpsychores.2015.03.142}, number={6}, volume={78}, issn={0022-3999}, journal={Journal of Psychosomatic Research}, author={Wirtz, Petra H.} }

eng 2017-08-09T09:58:04Z Higher body mass index (BMI) relates to lower glucocorticoid inhibition of inflammatory cytokine production following acute psychosocial stress in men Wirtz, Petra H. 2017-08-09T09:58:04Z Wirtz, Petra H. 2015-06 Background: Body mass index (BMI) and mental stress seem to exert part of their cardiovascular risk by eliciting inflammation but adverse effects of stress on inflammatory activity with BMI are not fully understood. We investigated whether higher BMI is associated with reduced glucocorticoid inhibition of inflammatory cytokine production following stress in men while controlling for age and blood pressure. We measured glucorticoid inhibition of lipopolysaccharide (LPS)-stimulated release of the proinflammatory cytokine tumor necrosis factor (TNF)-α.<br /><br />Method: Forty-two men (age range 21–65 years; body mass index (BMI) range 21–34 kg/m<sup>2</sup>) underwent the Trier Social Stress Test. Whole blood samples were taken immediately before and after stress, and during recovery up to 60 min post-stress. Glucocorticoid sensitivity of LPS-stimulated TNF-α expression was assessed in vitro with and without coincubating increasing doses of dexamethasone. Moreover, salivary cortisol was measured during the experiment and on a normal day for assessment of baseline circadian cortisol.<br /><br />Results: Higher BMI was associated with lower glucocorticoid sensitivity of monocyte TNF-α production after stress (main effect of BMI: p < 0.001) and with more pronounced decreases of glucocorticoid sensitivity following stress (interaction of stress-by-BMI: p = 0.002). Neither LPS-stimulated TNF-α release nor baseline glucocorticoid sensitivity was associated with BMI. Similarly, BMI was not associated with salivary cortisol, either in reaction to stress or in circadian cortisol secretion.<br /><br />Conclusion: Our data suggest that with increasing BMI, glucocorticoids are less able to inhibit TNF-α production following stress. This might suggest a new mechanism linking BMI with elevated risk for adverse cardiovascular outcomes following stress.

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