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WIPI3 and WIPI4 ß-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy

WIPI3 and WIPI4 ß-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy

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BAKULA, Daniela, Amelie J. MÜLLER, Theresia ZULEGER, Zsuzsanna TAKACS, Mirita FRANZ-WACHTEL, Ann-Katrin THOST, Daniel BRIGGER, Mario P. TSCHAN, Tancred FRICKEY, Horst ROBENEK, Boris MACEK, Tassula PROIKAS-CEZANNE, 2017. WIPI3 and WIPI4 ß-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy. In: Nature Communications. 8, 15637. eISSN 2041-1723. Available under: doi: 10.1038/ncomms15637

@article{Bakula2017WIPI3-39501, title={WIPI3 and WIPI4 ß-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy}, year={2017}, doi={10.1038/ncomms15637}, volume={8}, journal={Nature Communications}, author={Bakula, Daniela and Müller, Amelie J. and Zuleger, Theresia and Takacs, Zsuzsanna and Franz-Wachtel, Mirita and Thost, Ann-Katrin and Brigger, Daniel and Tschan, Mario P. and Frickey, Tancred and Robenek, Horst and Macek, Boris and Proikas-Cezanne, Tassula}, note={Article Number: 15637} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/39501"> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Bakula, Daniela</dc:creator> <dc:creator>Zuleger, Theresia</dc:creator> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/39501"/> <dcterms:title>WIPI3 and WIPI4 ß-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy</dcterms:title> <dc:creator>Franz-Wachtel, Mirita</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-07-06T09:07:08Z</dcterms:available> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/39501/1/Bakula_0-411080.pdf"/> <dc:contributor>Frickey, Tancred</dc:contributor> <dc:contributor>Thost, Ann-Katrin</dc:contributor> <dc:creator>Takacs, Zsuzsanna</dc:creator> <dc:creator>Brigger, Daniel</dc:creator> <dc:creator>Frickey, Tancred</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Proikas-Cezanne, Tassula</dc:creator> <dc:contributor>Macek, Boris</dc:contributor> <dcterms:abstract xml:lang="eng">Autophagy is controlled by AMPK and mTOR, both of which associate with ULK1 and control the production of phosphatidylinositol 3-phosphate (PtdIns3P), a prerequisite for autophagosome formation. Here we report that WIPI3 and WIPI4 scaffold the signal control of autophagy upstream of PtdIns3P production and have a role in the PtdIns3P effector function of WIPI1-WIPI2 at nascent autophagosomes. In response to LKB1-mediated AMPK stimulation, WIPI4-ATG2 is released from a WIPI4-ATG2/AMPK-ULK1 complex and translocates to nascent autophagosomes, controlling their size, to which WIPI3, in complex with FIP200, also contributes. Upstream, WIPI3 associates with AMPK-activated TSC complex at lysosomes, regulating mTOR. Our WIPI interactome analysis reveals the scaffold functions of WIPI proteins interconnecting autophagy signal control and autophagosome formation. Our functional kinase screen uncovers a novel regulatory link between LKB1-mediated AMPK stimulation that produces a direct signal via WIPI4, and we show that the AMPK-related kinases NUAK2 and BRSK2 regulate autophagy through WIPI4.</dcterms:abstract> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Müller, Amelie J.</dc:creator> <dc:contributor>Zuleger, Theresia</dc:contributor> <dc:creator>Thost, Ann-Katrin</dc:creator> <dc:contributor>Proikas-Cezanne, Tassula</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-07-06T09:07:08Z</dc:date> <dc:contributor>Müller, Amelie J.</dc:contributor> <dcterms:issued>2017</dcterms:issued> <dc:creator>Robenek, Horst</dc:creator> <dc:contributor>Brigger, Daniel</dc:contributor> <dc:contributor>Robenek, Horst</dc:contributor> <dc:contributor>Tschan, Mario P.</dc:contributor> <dc:contributor>Franz-Wachtel, Mirita</dc:contributor> <dc:creator>Macek, Boris</dc:creator> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/39501/1/Bakula_0-411080.pdf"/> <dc:language>eng</dc:language> <dc:contributor>Bakula, Daniela</dc:contributor> <dcterms:rights rdf:resource="http://nbn-resolving.de/urn:nbn:de:bsz:352-20150914100631302-4485392-8"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Takacs, Zsuzsanna</dc:contributor> <dc:creator>Tschan, Mario P.</dc:creator> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 06.07.2017 (Informationen über die Zugriffsstatistik)

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