Acetylene Hydratase : Part 5. Molybdenum/Tungsten

Cite This

Files in this item

Files Size Format View

There are no files associated with this item.

SEIFFERT, Grazyna B., Dietmar ABT, Felix TENBRINK, David FISCHER, Oliver EINSLE, Peter M. H. KRONECK, 2008. Acetylene Hydratase : Part 5. Molybdenum/Tungsten. In: MESSERSCHMIDT, Albrecht, ed.. Handbook of Metalloproteins. Chichester, UK:John Wiley & Sons, Ltd. ISBN 978-0-470-86981-9. Available under: doi: 10.1002/0470028637.met231

@incollection{Seiffert2008Acety-39244, title={Acetylene Hydratase : Part 5. Molybdenum/Tungsten}, year={2008}, doi={10.1002/0470028637.met231}, isbn={978-0-470-86981-9}, address={Chichester, UK}, publisher={John Wiley & Sons, Ltd}, booktitle={Handbook of Metalloproteins}, editor={Messerschmidt, Albrecht}, author={Seiffert, Grazyna B. and Abt, Dietmar and tenBrink, Felix and Fischer, David and Einsle, Oliver and Kroneck, Peter M. H.} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/39244"> <dc:creator>Fischer, David</dc:creator> <dc:creator>Abt, Dietmar</dc:creator> <dc:contributor>Abt, Dietmar</dc:contributor> <dc:contributor>Kroneck, Peter M. H.</dc:contributor> <dc:contributor>tenBrink, Felix</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/39244"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Kroneck, Peter M. H.</dc:creator> <dcterms:issued>2008</dcterms:issued> <dc:creator>Einsle, Oliver</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-06-13T09:23:28Z</dcterms:available> <dc:contributor>Einsle, Oliver</dc:contributor> <dc:creator>tenBrink, Felix</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:abstract xml:lang="eng">The tungsten-iron-sulfur enzyme acetylene hydratase is a rather unique enzyme within the class of tungsten/molybdenum enzymes in the sense that it catalyzes a nonredox reaction, the addition of one molecule of water to the C[TRIPLE BOND]C bond of acetylene to form acetaldehyde. Its crystal structure (1.26 Å) reveals a close to octahedral, or trigonal antiprismatic tungsten center, which binds a water molecule that gets activated by an adjacent aspartate residue such that it can attack an acetylene molecule bound in a distinct, hydrophobic pocket. This requires a strong shift of pKa of the aspartate, caused by a nearby low-potential [4Fe–4S] cluster. To gain access to this novel W-Asp-active site, the protein evolved a new substrate channel distant from where it is found in other molybdenum and tungsten enzymes.</dcterms:abstract> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:title>Acetylene Hydratase : Part 5. Molybdenum/Tungsten</dcterms:title> <dc:contributor>Fischer, David</dc:contributor> <dc:creator>Seiffert, Grazyna B.</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-06-13T09:23:28Z</dc:date> <dc:language>eng</dc:language> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Seiffert, Grazyna B.</dc:contributor> </rdf:Description> </rdf:RDF>

This item appears in the following Collection(s)

Search KOPS


Browse

My Account