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The impact of the CERAD-NP on diagnosis of cognitive deficiencies in late onset depression and Alzheimer's disease

The impact of the CERAD-NP on diagnosis of cognitive deficiencies in late onset depression and Alzheimer's disease

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KÜNIG, Gabriella, Michael JÄGER, Volker STIEF, Andreas KALDUNE, Frank URBANIOK, Jérôme ENDRASS, 2006. The impact of the CERAD-NP on diagnosis of cognitive deficiencies in late onset depression and Alzheimer's disease. In: International Journal of Geriatric Psychiatry. 21(10), pp. 911-916. ISSN 0885-6230. eISSN 1099-1166

@article{Kunig2006-10impac-38979, title={The impact of the CERAD-NP on diagnosis of cognitive deficiencies in late onset depression and Alzheimer's disease}, year={2006}, doi={10.1002/gps.1579}, number={10}, volume={21}, issn={0885-6230}, journal={International Journal of Geriatric Psychiatry}, pages={911--916}, author={Künig, Gabriella and Jäger, Michael and Stief, Volker and Kaldune, Andreas and Urbaniok, Frank and Endrass, Jérôme} }

2006-10 Urbaniok, Frank 2017-05-19T12:21:16Z Jäger, Michael Jäger, Michael eng Objectives<br />To identify the most appropriate test combination for distinguishing between late onset depression (LOD) and Alzheimer's disease (AD). To achieve this objective, the Consortium to Establish a Register for Alzheimer's Disease-Neuropsychological Battery (CERAD-NP) data of patients diagnosed with these two conditions were analyzed using multiple regression analysis.<br /><br />Methods<br />In the first regression analysis, the following CERAD-NP subtests were included: verbal fluency, Boston naming test, word list learning, constructional praxis, word list recall, and constructional praxis recall. In a second regression analysis, only CERAD-NP memory parameters were included: word list learning, word list recall, word list intrusions, word list savings, word list recognition, word list false positive errors, constructional praxis recall, and constructional praxis savings.<br /><br />Results<br />The combination of word list recall and constructional praxis recall best distinguished between LOD and AD, with a ROC of 0.91. In the stepwise regression of memory measures, word list recall, word list savings, and constructional praxis recall was the best combination, resulting in a ROC of 0.92.<br /><br />Conclusion<br />The most efficacious combination of the CERAD-NP battery for discriminating between LOD and AD consisted of word list recall and constructional praxis recall. Of the CERAD-NP memory measures, word list recall, word list savings, and constructional praxis recall represented the best diagnostic combination. Künig, Gabriella Endrass, Jérôme Endrass, Jérôme Kaldune, Andreas Künig, Gabriella 2017-05-19T12:21:16Z Urbaniok, Frank The impact of the CERAD-NP on diagnosis of cognitive deficiencies in late onset depression and Alzheimer's disease Stief, Volker Kaldune, Andreas Stief, Volker

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