Type of Publication: | Journal article |
Publication status: | Published |
Author: | Liebau, Christian; Merk, Harry; Roesel, Christian; Schmidt, Sebastian; Karreman, Christiaan; Prisack, Johannes Bernd; Bojar, Hans; Baltzer, Axel W. A. |
Year of publication: | 2002 |
Published in: | Anticancer Research ; 22 (2002), 5. - pp. 2559-2565. - ISSN 0250-7005. - eISSN 1791-7530 |
Pubmed ID: | 12529964 |
Summary: |
Gene therapy is a promising new method to treat tumors locally. Immuno-therapy for treatment of osteosarcomas is one option for hopefully improving the survival rate of patients with this tumor. Transduction of OS cells with the pCMV-IL-12neo plasmid induced a significant increase in IFN-gamma expression by mononuclear cells. This is known to induce antitumor effects mediated by the immune system. In combination with an administration of rIL-18, the IFN-gamma increase was multiplied in a dose-dependent manner. This study demonstrated that osteosarcoma cells can be targeted effectively in vitro by plasmids encoding the IL-12 gene. Considering the synergistic pathways it is reasonable to combine a local, gene transfer based on IL-12 with a rIL-18 administration to trigger the potentially promising immuno-effects for adjuvant treatment of osteosarcomas.
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Subject (DDC): | 570 Biosciences, Biology |
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LIEBAU, Christian, Harry MERK, Christian ROESEL, Sebastian SCHMIDT, Christiaan KARREMAN, Johannes Bernd PRISACK, Hans BOJAR, Axel W. A. BALTZER, 2002. rIL-18 triggered gene therapy based on a transduction with the IL-12 plasmid : a new option as immuno-therapy for osteosarcoma?. In: Anticancer Research. 22(5), pp. 2559-2565. ISSN 0250-7005. eISSN 1791-7530
@article{Liebau2002rIL18-38814, title={rIL-18 triggered gene therapy based on a transduction with the IL-12 plasmid : a new option as immuno-therapy for osteosarcoma?}, year={2002}, number={5}, volume={22}, issn={0250-7005}, journal={Anticancer Research}, pages={2559--2565}, author={Liebau, Christian and Merk, Harry and Roesel, Christian and Schmidt, Sebastian and Karreman, Christiaan and Prisack, Johannes Bernd and Bojar, Hans and Baltzer, Axel W. A.} }
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