KOPS - Das Institutionelle Repositorium der Universität Konstanz

rIL-18 triggered gene therapy based on a transduction with the IL-12 plasmid : a new option as immuno-therapy for osteosarcoma?

rIL-18 triggered gene therapy based on a transduction with the IL-12 plasmid : a new option as immuno-therapy for osteosarcoma?

Zitieren

Dateien zu dieser Ressource

Dateien Größe Format Anzeige

Zu diesem Dokument gibt es keine Dateien.

LIEBAU, Christian, Harry MERK, Christian ROESEL, Sebastian SCHMIDT, Christiaan KARREMAN, Johannes Bernd PRISACK, Hans BOJAR, Axel W. A. BALTZER, 2002. rIL-18 triggered gene therapy based on a transduction with the IL-12 plasmid : a new option as immuno-therapy for osteosarcoma?. In: Anticancer Research. 22(5), pp. 2559-2565. ISSN 0250-7005. eISSN 1791-7530

@article{Liebau2002rIL-1-38814, title={rIL-18 triggered gene therapy based on a transduction with the IL-12 plasmid : a new option as immuno-therapy for osteosarcoma?}, year={2002}, number={5}, volume={22}, issn={0250-7005}, journal={Anticancer Research}, pages={2559--2565}, author={Liebau, Christian and Merk, Harry and Roesel, Christian and Schmidt, Sebastian and Karreman, Christiaan and Prisack, Johannes Bernd and Bojar, Hans and Baltzer, Axel W. A.} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/38814"> <dc:creator>Prisack, Johannes Bernd</dc:creator> <dc:contributor>Roesel, Christian</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-05-09T11:11:11Z</dc:date> <dc:creator>Karreman, Christiaan</dc:creator> <dc:creator>Baltzer, Axel W. A.</dc:creator> <dc:creator>Roesel, Christian</dc:creator> <dcterms:issued>2002</dcterms:issued> <dcterms:abstract xml:lang="eng">Gene therapy is a promising new method to treat tumors locally. Immuno-therapy for treatment of osteosarcomas is one option for hopefully improving the survival rate of patients with this tumor. Transduction of OS cells with the pCMV-IL-12neo plasmid induced a significant increase in IFN-gamma expression by mononuclear cells. This is known to induce antitumor effects mediated by the immune system. In combination with an administration of rIL-18, the IFN-gamma increase was multiplied in a dose-dependent manner. This study demonstrated that osteosarcoma cells can be targeted effectively in vitro by plasmids encoding the IL-12 gene. Considering the synergistic pathways it is reasonable to combine a local, gene transfer based on IL-12 with a rIL-18 administration to trigger the potentially promising immuno-effects for adjuvant treatment of osteosarcomas.</dcterms:abstract> <dc:language>eng</dc:language> <dc:creator>Bojar, Hans</dc:creator> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/38814"/> <dc:contributor>Schmidt, Sebastian</dc:contributor> <dcterms:title>rIL-18 triggered gene therapy based on a transduction with the IL-12 plasmid : a new option as immuno-therapy for osteosarcoma?</dcterms:title> <dc:contributor>Karreman, Christiaan</dc:contributor> <dc:contributor>Bojar, Hans</dc:contributor> <dc:creator>Liebau, Christian</dc:creator> <dc:contributor>Baltzer, Axel W. A.</dc:contributor> <dc:contributor>Merk, Harry</dc:contributor> <dc:contributor>Liebau, Christian</dc:contributor> <dc:creator>Merk, Harry</dc:creator> <dc:creator>Schmidt, Sebastian</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-05-09T11:11:11Z</dcterms:available> <dc:contributor>Prisack, Johannes Bernd</dc:contributor> </rdf:Description> </rdf:RDF>

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto