KOPS - Das Institutionelle Repositorium der Universität Konstanz

Immunotherapy by gene transfer with plasmids encoding IL-12/IL-18 is superior to IL-23/IL-18 gene transfer in a rat osteosarcoma model

Immunotherapy by gene transfer with plasmids encoding IL-12/IL-18 is superior to IL-23/IL-18 gene transfer in a rat osteosarcoma model

Zitieren

Dateien zu dieser Ressource

Dateien Größe Format Anzeige

Zu diesem Dokument gibt es keine Dateien.

LIEBAU, Christian, Christian ROESEL, Sebastian SCHMIDT, Christiaan KARREMAN, Johannes Bernd PRISACK, Hans BOJAR, Harry MERK, Neumann WOLFRAM, Axel W. A. BALTZER, 2004. Immunotherapy by gene transfer with plasmids encoding IL-12/IL-18 is superior to IL-23/IL-18 gene transfer in a rat osteosarcoma model. In: Anticancer Research. 24(5A), pp. 2861-2867. ISSN 0250-7005. eISSN 1791-7530

@article{Liebau2004Immun-38813, title={Immunotherapy by gene transfer with plasmids encoding IL-12/IL-18 is superior to IL-23/IL-18 gene transfer in a rat osteosarcoma model}, year={2004}, number={5A}, volume={24}, issn={0250-7005}, journal={Anticancer Research}, pages={2861--2867}, author={Liebau, Christian and Roesel, Christian and Schmidt, Sebastian and Karreman, Christiaan and Prisack, Johannes Bernd and Bojar, Hans and Merk, Harry and Wolfram, Neumann and Baltzer, Axel W. A.} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/38813"> <dc:contributor>Karreman, Christiaan</dc:contributor> <dc:language>eng</dc:language> <dc:contributor>Liebau, Christian</dc:contributor> <dc:creator>Merk, Harry</dc:creator> <dc:creator>Karreman, Christiaan</dc:creator> <dc:creator>Wolfram, Neumann</dc:creator> <dc:creator>Roesel, Christian</dc:creator> <dc:contributor>Baltzer, Axel W. A.</dc:contributor> <dc:contributor>Wolfram, Neumann</dc:contributor> <dcterms:issued>2004</dcterms:issued> <dc:contributor>Roesel, Christian</dc:contributor> <dc:contributor>Merk, Harry</dc:contributor> <dc:creator>Bojar, Hans</dc:creator> <dcterms:title>Immunotherapy by gene transfer with plasmids encoding IL-12/IL-18 is superior to IL-23/IL-18 gene transfer in a rat osteosarcoma model</dcterms:title> <dc:creator>Liebau, Christian</dc:creator> <dc:creator>Prisack, Johannes Bernd</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-05-09T11:07:32Z</dcterms:available> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/38813"/> <dc:contributor>Prisack, Johannes Bernd</dc:contributor> <dcterms:abstract xml:lang="eng">Osteosarcomas are primary malignant tumors of bone or soft parts arising from bone-forming mesenchymal cells. Despite dramatic therapeutic advances, namely neo-adjuvant and adjuvant chemotherapy, progress is at a plateau. Cytokine-mediated gene therapy might represent a further advance in the therapy of the osteosarcoma. Materials and Methods: We transfected UMR 108 osteosarcoma cells with different plasmids encoding IL-12, IL-23, proIL-18 and ICE (Interleukin-converting enzyme). IFN-γ induction, which is known to induce antitumor effects mediated by the immune system, and cytotoxic effects of various cytokine combination were investigated. Results: Our results show that local secretion of IL-12 by UMR 108 cells led to an induction of cytotoxic effects mediated by mononuclear cells, which were enhanced by additional administration of recombinant IL-18. In contrast to IL-18, IL-23 showed a moderate increase of IFN-γ induction when transfected alone and could only slightly increase the IFN-γ induction mediated by IL-12. IL-18 enhanced IFN-γ induction when applied alone and was able to increase the IFN-γ production that was induced by IL-12. Conclusion: IL-23 seems to be a less effective immuno-therapeutic for adjuvant treatment of osteosarcomas than IL-12 and IL-18, when taking only IFN-γ induction into consideration.</dcterms:abstract> <dc:contributor>Schmidt, Sebastian</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-05-09T11:07:32Z</dc:date> <dc:creator>Baltzer, Axel W. A.</dc:creator> <dc:contributor>Bojar, Hans</dc:contributor> <dc:creator>Schmidt, Sebastian</dc:creator> </rdf:Description> </rdf:RDF>

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto