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Interleukin-12 and interleukin-18 change ICAM-I expression, and enhance natural killer cell mediated cytolysis of human osteosarcoma cells

Interleukin-12 and interleukin-18 change ICAM-I expression, and enhance natural killer cell mediated cytolysis of human osteosarcoma cells

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LIEBAU, Christian, Harry MERK, Sebastian SCHMIDT, Christian ROESEL, Christiaan KARREMAN, Johannes Bernd PRISACK, Hans BOJAR, Axel W. A. BALTZER, 2002. Interleukin-12 and interleukin-18 change ICAM-I expression, and enhance natural killer cell mediated cytolysis of human osteosarcoma cells. In: Cytokines, Cellular & Molecular Therapy. 7(4), pp. 135-142. ISSN 1368-4736. eISSN 1471-177X

@article{Liebau2002Inter-38766, title={Interleukin-12 and interleukin-18 change ICAM-I expression, and enhance natural killer cell mediated cytolysis of human osteosarcoma cells}, year={2002}, doi={10.1080/13684730310001977}, number={4}, volume={7}, issn={1368-4736}, journal={Cytokines, Cellular & Molecular Therapy}, pages={135--142}, author={Liebau, Christian and Merk, Harry and Schmidt, Sebastian and Roesel, Christian and Karreman, Christiaan and Prisack, Johannes Bernd and Bojar, Hans and Baltzer, Axel W. A.} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/38766"> <dc:creator>Roesel, Christian</dc:creator> <dc:contributor>Liebau, Christian</dc:contributor> <dc:language>eng</dc:language> <dc:contributor>Merk, Harry</dc:contributor> <dc:creator>Baltzer, Axel W. A.</dc:creator> <dc:creator>Merk, Harry</dc:creator> <dc:creator>Liebau, Christian</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-05-08T08:30:04Z</dcterms:available> <dc:contributor>Baltzer, Axel W. A.</dc:contributor> <dc:contributor>Bojar, Hans</dc:contributor> <dc:contributor>Roesel, Christian</dc:contributor> <dcterms:title>Interleukin-12 and interleukin-18 change ICAM-I expression, and enhance natural killer cell mediated cytolysis of human osteosarcoma cells</dcterms:title> <dc:contributor>Prisack, Johannes Bernd</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-05-08T08:30:04Z</dc:date> <dc:contributor>Schmidt, Sebastian</dc:contributor> <dcterms:abstract xml:lang="eng">Cytokines play important roles in the expression of adhesion molecules and the function of anti-tumor effector cells in the immune system. In this study, the influence of interleukin-12 (IL-12) and IL-18 on the expression of ICAM-1 and natural killer (NK)-cell mediated lysis in a human osteosarcoma cell line (HOS) was evaluated. ICAM-I expression of HOS cells were analyzed by flow cytometry following treatment with IL-12, IL-18 or both, and in co-cultures with peripheral lymphocytes. NK-cell activation in response to IL-12 and IL-18 was investigated by selective flow cytometry using propidium iodide. ICAM-1 expression on HOS cells was significantly enhanced by IL-12, but only when co-cultured in cell-to-cell contact with peripheral lymphocytes. Antibodies to interferon-gamma abrogated this effect. If HOS cells and peripheral lymphocytes were separated in co-cultures, IL-18 could substitute for cell-to-cell contact, facilitating IL-12-mediated enhancement of ICAM-1. Addition of IL-18 also enhanced NK-mediated cytolysis of HOS cells. These findings demonstrate that IL-12 can enhance the expression of ICAM-1 in the presence of IFN-gamma and, with IL-18, enhances NK anti-tumor activity. Immunomodulation via cytokine therapy may lead to improved eradication of chemotherapy-resistant osteosarcomas.</dcterms:abstract> <dc:creator>Prisack, Johannes Bernd</dc:creator> <dcterms:issued>2002</dcterms:issued> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/38766"/> <dc:creator>Bojar, Hans</dc:creator> <dc:contributor>Karreman, Christiaan</dc:contributor> <dc:creator>Karreman, Christiaan</dc:creator> <dc:creator>Schmidt, Sebastian</dc:creator> </rdf:Description> </rdf:RDF>

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