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Disruption of Tumor Cell Adhesion Promotes Angiogenic Switch and Progression to Micrometastasis in RAF-Driven Murine Lung Cancer

Disruption of Tumor Cell Adhesion Promotes Angiogenic Switch and Progression to Micrometastasis in RAF-Driven Murine Lung Cancer

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CETECI, Fatih, Semra CETECI, Christiaan KARREMAN, Boris W. KRAMER, Esther ASAN, Rudolf GÖTZ, Ulf R. RAPP, 2007. Disruption of Tumor Cell Adhesion Promotes Angiogenic Switch and Progression to Micrometastasis in RAF-Driven Murine Lung Cancer. In: Cancer Cell. 12(2), pp. 145-159. ISSN 1535-6108. eISSN 1878-3686

@article{Ceteci2007-08Disru-38680, title={Disruption of Tumor Cell Adhesion Promotes Angiogenic Switch and Progression to Micrometastasis in RAF-Driven Murine Lung Cancer}, year={2007}, doi={10.1016/j.ccr.2007.06.014}, number={2}, volume={12}, issn={1535-6108}, journal={Cancer Cell}, pages={145--159}, author={Ceteci, Fatih and Ceteci, Semra and Karreman, Christiaan and Kramer, Boris W. and Asan, Esther and Götz, Rudolf and Rapp, Ulf R.} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/38680"> <dc:creator>Kramer, Boris W.</dc:creator> <dc:creator>Karreman, Christiaan</dc:creator> <dc:creator>Rapp, Ulf R.</dc:creator> <dc:contributor>Karreman, Christiaan</dc:contributor> <dc:creator>Ceteci, Fatih</dc:creator> <dcterms:issued>2007-08</dcterms:issued> <dc:contributor>Rapp, Ulf R.</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-05-02T09:15:17Z</dcterms:available> <dcterms:abstract xml:lang="eng">Progression of non-small-cell lung cancer (NSCLC) to metastasis is poorly understood. Two genetic approaches were used to evaluate the role of adherens junctions in a C-RAF driven mouse model for NSCLC: conditional ablation of the cdh1 gene and expression of dominant-negative (dn) E-cadherin. Disruption of E-cadherin caused massive formation of intratumoral vessels that was reversible in the early phase of induction. Vascularized tumors grew more rapidly, developed invasive fronts, and gave rise to micrometastasis. beta-catenin was identified as a critical effector of E-cadherin disruption leading to upregulation of VEGF-A and VEGF-C. In vivo, lung tumor cells with disrupted E-cadherin expressed beta-catenin target genes normally found in other endodermal lineages suggesting that reprogramming may be involved in metastatic progression.</dcterms:abstract> <dc:creator>Ceteci, Semra</dc:creator> <dc:contributor>Ceteci, Fatih</dc:contributor> <dc:contributor>Asan, Esther</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-05-02T09:15:17Z</dc:date> <dc:contributor>Götz, Rudolf</dc:contributor> <dc:language>eng</dc:language> <dcterms:title>Disruption of Tumor Cell Adhesion Promotes Angiogenic Switch and Progression to Micrometastasis in RAF-Driven Murine Lung Cancer</dcterms:title> <dc:contributor>Ceteci, Semra</dc:contributor> <dc:creator>Götz, Rudolf</dc:creator> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/38680"/> <dc:creator>Asan, Esther</dc:creator> <dc:contributor>Kramer, Boris W.</dc:contributor> </rdf:Description> </rdf:RDF>

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