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Detailed assessment of the hemodynamic response to psychosocial stress using real-time MRI

Detailed assessment of the hemodynamic response to psychosocial stress using real-time MRI

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JONES, Alexander, Jennifer A. STEEDEN, Jens C. PRUESSNER, John E. DEANFIELD, Andrew M. TAYLOR, Vivek MUTHURANGU, 2011. Detailed assessment of the hemodynamic response to psychosocial stress using real-time MRI. In: Journal of Magnetic Resonance Imaging : JMRI. 33(2), pp. 448-454. ISSN 1053-1807. eISSN 1522-2586

@article{Jones2011Detai-38557, title={Detailed assessment of the hemodynamic response to psychosocial stress using real-time MRI}, year={2011}, doi={10.1002/jmri.22438}, number={2}, volume={33}, issn={1053-1807}, journal={Journal of Magnetic Resonance Imaging : JMRI}, pages={448--454}, author={Jones, Alexander and Steeden, Jennifer A. and Pruessner, Jens C. and Deanfield, John E. and Taylor, Andrew M. and Muthurangu, Vivek} }

Taylor, Andrew M. Purpose<br /><br />To demonstrate that combining the Montreal Imaging Stress Task (MIST) with real-time cardiac magnetic resonance imaging (MRI) allows detailed assessment of the cardiovascular mental stress response.<br /><br />Materials and Methods<br /><br />22 healthy volunteers (1:1 M:F, 26–64 years) underwent MRI during rest and the MIST. Real-time spiral phase contrast MR, accelerated with sensitivity encoding (SENSE) was used to assess stroke volume (SV), and radial k-t SENSE was used to assess ventricular volumes. Simultaneous heart rate (HR) and blood pressure (BP) measures allowed calculation of cardiac output (CO), systemic vascular resistance (SVR), and arterial compliance (TAC). Endocrine responses were assessed using salivary cortisol.<br /><br />Results<br /><br />In response to stress, BP increased due to increased CO and reduced TAC but not increased SVR, which fell. HR, not SV, determined CO increases. Greater BP responses occurred in men due to greater CO increases and relatively higher SVR. Older participants had greater BP responses due to greater falls in TAC. Greater cortisol response was correlated with greater falls in TAC but resting cortisol and TAC were not related.<br /><br />Conclusion<br /><br />This new approach allows detailed, accurate assessment of stress physiology. Preliminary findings suggest stress exposes relationships, not seen at rest, of cardiovascular function with age, sex, and endocrine function. Pruessner, Jens C. Muthurangu, Vivek Deanfield, John E. Taylor, Andrew M. Jones, Alexander Deanfield, John E. Detailed assessment of the hemodynamic response to psychosocial stress using real-time MRI 2011 Jones, Alexander eng Steeden, Jennifer A. 2017-04-21T12:30:11Z Muthurangu, Vivek 2017-04-21T12:30:11Z Steeden, Jennifer A. Pruessner, Jens C.

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