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COMT Val<sup>158</sup>Met Genotype Selectively Alters Prefrontal [<sup>18</sup>F]Fallypride Displacement and Subjective Feelings of Stress in Response to a Psychosocial Stress Challenge

COMT Val158Met Genotype Selectively Alters Prefrontal [18F]Fallypride Displacement and Subjective Feelings of Stress in Response to a Psychosocial Stress Challenge

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Prüfsumme: MD5:a68d094717d26984c95f37b9c59b0f5e

HERNAUS, Dennis, Dina COLLIP, Johan LATASTER, Jenny CECCARINI, Gunther KENIS, Linda BOOIJ, Jens PRUESSNER, Koen VAN LAERE, Ruud VAN WINKEL, Inez MYIN-GERMEYS, 2013. COMT Val158Met Genotype Selectively Alters Prefrontal [18F]Fallypride Displacement and Subjective Feelings of Stress in Response to a Psychosocial Stress Challenge. In: PLoS ONE. 8(6), e65662. eISSN 1932-6203. Available under: doi: 10.1371/journal.pone.0065662

@article{Hernaus2013-06-14Genot-38532, title={COMT Val158Met Genotype Selectively Alters Prefrontal [18F]Fallypride Displacement and Subjective Feelings of Stress in Response to a Psychosocial Stress Challenge}, year={2013}, doi={10.1371/journal.pone.0065662}, number={6}, volume={8}, journal={PLoS ONE}, author={Hernaus, Dennis and Collip, Dina and Lataster, Johan and Ceccarini, Jenny and Kenis, Gunther and Booij, Linda and Pruessner, Jens and Van Laere, Koen and van Winkel, Ruud and Myin-Germeys, Inez}, note={Article Number: e65662} }

2017-04-20T09:29:24Z COMT Val<sup>158</sup>Met Genotype Selectively Alters Prefrontal [<sup>18</sup>F]Fallypride Displacement and Subjective Feelings of Stress in Response to a Psychosocial Stress Challenge Collip, Dina Lataster, Johan Kenis, Gunther Myin-Germeys, Inez Catechol-O-methyltransferase (COMT) plays an essential role in degradation of extracellular dopamine in prefrontal regions of the brain. Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress little is known about its effect on dopaminergic activity associated with the human stress response, which may be of interest for stress-related psychiatric disorders such as psychosis. We aimed to investigate the effect of variations in COMT genotype on in vivo measures of stress-induced prefrontal cortex (PFC) dopaminergic processing and subjective stress responses. A combined sample of healthy controls and healthy first-degree relatives of psychosis patients (n = 26) were subjected to an [(18)F]fallypride Positron Emission Tomography scan. Psychosocial stress during the scan was induced using the Montreal Imaging Stress Task and subjective stress was assessed every 12 minutes. Parametric t-maps, generated using the linear extension of the simplified reference region model, revealed an effect of COMT genotype on the spatial extent of [(18)F]fallypride displacement. Detected effects of exposure to psychosocial stress were unilateral and remained restricted to the left superior and right inferior frontal gyrus, with Met-hetero- and homozygotes showing less [(18)F]fallypride displacement than Val-homozygotes. Additionally, Met-hetero- and homozygotes experienced larger subjective stress responses than Val-homozygotes. The direction of the effects remained the same when the data was analyzed separately for controls and first-degree relatives. The human stress response may be mediated in part by COMT-dependent dopaminergic PFC activity, providing speculation for the neurobiology underlying COMT-dependent differences in human behaviour following stress. Implications of these results for stress-related psychopathology and models of dopaminergic functioning are discussed. Kenis, Gunther Ceccarini, Jenny Collip, Dina Booij, Linda Pruessner, Jens van Winkel, Ruud Lataster, Johan Hernaus, Dennis 2017-04-20T09:29:24Z eng van Winkel, Ruud Van Laere, Koen Pruessner, Jens Myin-Germeys, Inez Van Laere, Koen Hernaus, Dennis Ceccarini, Jenny Booij, Linda 2013-06-14

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