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Signalling processes in endothelial ageing in relation to chronic oxidative stress and their potential therapeutic implications in humans

Signalling processes in endothelial ageing in relation to chronic oxidative stress and their potential therapeutic implications in humans

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VAN DER LOO, Bernd, Stefan SCHILDKNECHT, Rebecca ZEE, Markus M. BACHSCHMID, 2009. Signalling processes in endothelial ageing in relation to chronic oxidative stress and their potential therapeutic implications in humans. In: Experimental Physiology. 94(3), pp. 305-310. ISSN 0958-0670. eISSN 1469-445X

@article{Van Der Loo2009-03Signa-38526, title={Signalling processes in endothelial ageing in relation to chronic oxidative stress and their potential therapeutic implications in humans}, year={2009}, doi={10.1113/expphysiol.2008.043315}, number={3}, volume={94}, issn={0958-0670}, journal={Experimental Physiology}, pages={305--310}, author={Van Der Loo, Bernd and Schildknecht, Stefan and Zee, Rebecca and Bachschmid, Markus M.} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/38526"> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-04-20T07:01:03Z</dc:date> <dc:contributor>Van Der Loo, Bernd</dc:contributor> <dc:creator>Zee, Rebecca</dc:creator> <dc:contributor>Zee, Rebecca</dc:contributor> <dcterms:issued>2009-03</dcterms:issued> <dc:creator>Van Der Loo, Bernd</dc:creator> <dc:contributor>Bachschmid, Markus M.</dc:contributor> <dc:language>eng</dc:language> <dc:contributor>Schildknecht, Stefan</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-04-20T07:01:03Z</dcterms:available> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/38526"/> <dc:creator>Schildknecht, Stefan</dc:creator> <dcterms:abstract xml:lang="eng">Ageing is an important risk factor for the development of cardiovascular diseases. Vascular ageing is mainly characterized by endothelial dysfunction, an alteration of endothelium-dependent signalling processes and vascular remodelling. The underlying mechanisms comprise increased production of reactive oxygen species (ROS), inactivation of nitric oxide (.NO) and subsequent formation of peroxynitrite (ONOO(-)). Elevated ONOO(-) may exhibit new messenger functions by post-translational oxidative modification of intracellular regulatory proteins. Mitochondria are a major source of age-associated superoxide formation, as electrons are misdirected from the respiratory chain. Manganese superoxide dismutase (MnSOD), a mitochondrial antioxidant enzyme, is an integral part of the nucleoids and may protect mitochondrial DNA from ROS. A model linking .NO, mitochondria, MnSOD and its acetylation/deacetylation by sirtuins (NAD+-dependent class III histone deacetylases) may be the basis for a potentially new powerful therapeutic intervention in the ageing process.</dcterms:abstract> <dcterms:title>Signalling processes in endothelial ageing in relation to chronic oxidative stress and their potential therapeutic implications in humans</dcterms:title> <dc:creator>Bachschmid, Markus M.</dc:creator> </rdf:Description> </rdf:RDF>

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