Arginine methylation of the B cell antigen receptor promotes differentiation
| Publikationstyp: | Zeitschriftenartikel |
| Publikationsstatus: | Published |
| Autor/innen: | Infantino, Simona; Benz, Beate; Waldmann, Tanja; Jung, Manfred; Schneider, Robert; Reth, Michael |
| Erscheinungsjahr: | 2010 |
| Erschienen in: | The Journal of Experimental Medicine : JEM ; 207 (2010), 4. - S. 711-719. - ISSN 0022-1007. - eISSN 1540-9538 |
| Pubmed ID: | 20231378 |
| DOI (zitierfähiger Link): | https://dx.doi.org/10.1084/jem.20091303 |
| Zusammenfassung: |
Signals processed through the B cell antigen receptor (BCR) control both the proliferation and differentiation of B lymphocytes. How these different signaling modes are established at the BCR is poorly understood. We show that a conserved arginine in the tail sequence of the Igalpha subunit of the BCR is methylated by the protein arginine methyltransferase 1. This modification negatively regulates the calcium and PI-3 kinase pathways of the BCR while promoting signals leading to B cell differentiation. Thus, Igalpha arginine methylation can play an important role in specifying the outcome of BCR signaling.
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| Fachgebiet (DDC): | 570 Biowissenschaften, Biologie |
| Universitätsbibliographie: | Ja |
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INFANTINO, Simona, Beate BENZ, Tanja WALDMANN, Manfred JUNG, Robert SCHNEIDER, Michael RETH, 2010. Arginine methylation of the B cell antigen receptor promotes differentiation. In: The Journal of Experimental Medicine : JEM. 207(4), pp. 711-719. ISSN 0022-1007. eISSN 1540-9538
@article{Infantino2010-04-12Argin-38525, title={Arginine methylation of the B cell antigen receptor promotes differentiation}, year={2010}, doi={10.1084/jem.20091303}, number={4}, volume={207}, issn={0022-1007}, journal={The Journal of Experimental Medicine : JEM}, pages={711--719}, author={Infantino, Simona and Benz, Beate and Waldmann, Tanja and Jung, Manfred and Schneider, Robert and Reth, Michael} }
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