Arginine methylation of the B cell antigen receptor promotes differentiation
| Type of Publication: | Journal article |
| Publication status: | Published |
| Author: | Infantino, Simona; Benz, Beate; Waldmann, Tanja; Jung, Manfred; Schneider, Robert; Reth, Michael |
| Year of publication: | 2010 |
| Published in: | The Journal of Experimental Medicine : JEM ; 207 (2010), 4. - pp. 711-719. - ISSN 0022-1007. - eISSN 1540-9538 |
| Pubmed ID: | 20231378 |
| DOI (citable link): | https://dx.doi.org/10.1084/jem.20091303 |
| Summary: |
Signals processed through the B cell antigen receptor (BCR) control both the proliferation and differentiation of B lymphocytes. How these different signaling modes are established at the BCR is poorly understood. We show that a conserved arginine in the tail sequence of the Igalpha subunit of the BCR is methylated by the protein arginine methyltransferase 1. This modification negatively regulates the calcium and PI-3 kinase pathways of the BCR while promoting signals leading to B cell differentiation. Thus, Igalpha arginine methylation can play an important role in specifying the outcome of BCR signaling.
|
| Subject (DDC): | 570 Biosciences, Biology |
| Bibliography of Konstanz: | Yes |
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INFANTINO, Simona, Beate BENZ, Tanja WALDMANN, Manfred JUNG, Robert SCHNEIDER, Michael RETH, 2010. Arginine methylation of the B cell antigen receptor promotes differentiation. In: The Journal of Experimental Medicine : JEM. 207(4), pp. 711-719. ISSN 0022-1007. eISSN 1540-9538. Available under: doi: 10.1084/jem.20091303
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