Arginine methylation of the B cell antigen receptor promotes differentiation

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INFANTINO, Simona, Beate BENZ, Tanja WALDMANN, Manfred JUNG, Robert SCHNEIDER, Michael RETH, 2010. Arginine methylation of the B cell antigen receptor promotes differentiation. In: The Journal of Experimental Medicine : JEM. 207(4), pp. 711-719. ISSN 0022-1007. eISSN 1540-9538

@article{Infantino2010-04-12Argin-38525, title={Arginine methylation of the B cell antigen receptor promotes differentiation}, year={2010}, doi={10.1084/jem.20091303}, number={4}, volume={207}, issn={0022-1007}, journal={The Journal of Experimental Medicine : JEM}, pages={711--719}, author={Infantino, Simona and Benz, Beate and Waldmann, Tanja and Jung, Manfred and Schneider, Robert and Reth, Michael} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/38525"> <dc:contributor>Benz, Beate</dc:contributor> <dc:creator>Schneider, Robert</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-04-20T06:56:48Z</dc:date> <dc:creator>Waldmann, Tanja</dc:creator> <dcterms:abstract xml:lang="eng">Signals processed through the B cell antigen receptor (BCR) control both the proliferation and differentiation of B lymphocytes. How these different signaling modes are established at the BCR is poorly understood. We show that a conserved arginine in the tail sequence of the Igalpha subunit of the BCR is methylated by the protein arginine methyltransferase 1. This modification negatively regulates the calcium and PI-3 kinase pathways of the BCR while promoting signals leading to B cell differentiation. Thus, Igalpha arginine methylation can play an important role in specifying the outcome of BCR signaling.</dcterms:abstract> <dc:contributor>Reth, Michael</dc:contributor> <dc:creator>Infantino, Simona</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-04-20T06:56:48Z</dcterms:available> <dc:contributor>Schneider, Robert</dc:contributor> <dc:creator>Benz, Beate</dc:creator> <dc:creator>Reth, Michael</dc:creator> <dc:contributor>Jung, Manfred</dc:contributor> <dc:language>eng</dc:language> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/38525"/> <dc:creator>Jung, Manfred</dc:creator> <dc:contributor>Infantino, Simona</dc:contributor> <dcterms:issued>2010-04-12</dcterms:issued> <dc:contributor>Waldmann, Tanja</dc:contributor> <dcterms:title>Arginine methylation of the B cell antigen receptor promotes differentiation</dcterms:title> </rdf:Description> </rdf:RDF>

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