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Familial Liability to Psychosis Is Associated With Attenuated Dopamine Stress Signaling in Ventromedial Prefrontal Cortex

Familial Liability to Psychosis Is Associated With Attenuated Dopamine Stress Signaling in Ventromedial Prefrontal Cortex

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LATASTER, Johan, Dina COLLIP, Jenny CECCARINI, Dennis HERNAUS, David HAAS, Linda BOOIJ, Jim VAN OS, Jens PRÜSSNER, Koen VAN LAERE, Inez MYIN-GERMEYS, 2014. Familial Liability to Psychosis Is Associated With Attenuated Dopamine Stress Signaling in Ventromedial Prefrontal Cortex. In: Schizophrenia Bulletin. 40(1), pp. 66-77. ISSN 0586-7614. eISSN 1745-1701. Available under: doi: 10.1093/schbul/sbs187

@article{Lataster2014-01-08Famil-38522, title={Familial Liability to Psychosis Is Associated With Attenuated Dopamine Stress Signaling in Ventromedial Prefrontal Cortex}, year={2014}, doi={10.1093/schbul/sbs187}, number={1}, volume={40}, issn={0586-7614}, journal={Schizophrenia Bulletin}, pages={66--77}, author={Lataster, Johan and Collip, Dina and Ceccarini, Jenny and Hernaus, Dennis and Haas, David and Booij, Linda and van Os, Jim and Prüßner, Jens and Van Laere, Koen and Myin-Germeys, Inez} }

Myin-Germeys, Inez Collip, Dina Van Laere, Koen Familial Liability to Psychosis Is Associated With Attenuated Dopamine Stress Signaling in Ventromedial Prefrontal Cortex Haas, David Lataster, Johan Haas, David Hernaus, Dennis Objective<br /><br />Patients diagnosed with a psychotic disorder and their first-degree relatives display increased reactivity to stress. Theory predicts that experience of psychosocial stress is associated both with ventromedial prefrontal and mesolimbic dopamine neurotransmission. However, while there is evidence of aberrant striatal dopamine processing in psychotic disorder, the role of the prefrontal cortex remains under-researched. This study aimed at investigating stress-induced in vivo dopamine release in ventromedial prefrontal cortex (vmPFC) of individuals at familial risk for psychosis.<br /><br />Method<br /><br />Fourteen healthy first-degree relatives of patients with a diagnosis of psychotic disorder and 10 control subjects underwent a single dynamic positron emission tomography (PET) scanning session after intravenous administration of 183.2 (SD = 7.6) MBq [<sup>18</sup>F]fallypride. Psychosocial stress was initiated at 100min postinjection using a computerized mental arithmetic task with social evaluative threat components. PET data were analyzed using the linearized simplified reference region model. Regression analyses were performed to compare the spatial extent of task-related ligand displacement between control subjects and relatives and to find how it related to self-rated experiences of psychosocial stress and psychosis.<br /><br />Results<br /><br />First-degree relatives displayed hyporeactive dopamine signaling in the vmPFC in response to stress. Increased levels of subjectively rated stress were associated with increased intensity of psychotic experiences. This effect was particularly pronounced in first-degree relatives.<br /><br />Conclusion<br /><br />Although previous studies have hypothesized a role for prefrontal dopamine dysfunction in psychosis, this study, to our knowledge, is the first in vivo human imaging study showing attenuated (ie, hyporeactive) dopamine stress neuromodulation in vmPFC of individuals at familial risk for psychosis. Collip, Dina Prüßner, Jens van Os, Jim Ceccarini, Jenny 2017-04-19T09:10:59Z Booij, Linda Booij, Linda Prüßner, Jens Ceccarini, Jenny 2017-04-19T09:10:59Z Van Laere, Koen Hernaus, Dennis eng van Os, Jim Myin-Germeys, Inez 2014-01-08 Lataster, Johan

Dateiabrufe seit 19.04.2017 (Informationen über die Zugriffsstatistik)

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