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No evidence for attenuated stress-induced extrastriatal dopamine signaling in psychotic disorder

No evidence for attenuated stress-induced extrastriatal dopamine signaling in psychotic disorder

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Prüfsumme: MD5:df0d4c29469a36954d4d42dae439ab33

HERNAUS, Dennis, Dina COLLIP, Zuzana KASANOVA, Oliver WINZ, Alexander HEINZEL, Therese VAN AMELSVOORT, Siamak Mohammadkhani SHALI, Jan BOOIJ, Jens PRÜSSNER, Inez MYIN-GERMEYS, 2015. No evidence for attenuated stress-induced extrastriatal dopamine signaling in psychotic disorder. In: Translational Psychiatry. 5, e547. eISSN 2158-3188

@article{Hernaus2015-04-14evide-38497, title={No evidence for attenuated stress-induced extrastriatal dopamine signaling in psychotic disorder}, year={2015}, doi={10.1038/tp.2015.37}, volume={5}, journal={Translational Psychiatry}, author={Hernaus, Dennis and Collip, Dina and Kasanova, Zuzana and Winz, Oliver and Heinzel, Alexander and van Amelsvoort, Therese and Shali, Siamak Mohammadkhani and Booij, Jan and Prüßner, Jens and Myin-Germeys, Inez}, note={Article Number: e547} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/38497"> <dc:contributor>Winz, Oliver</dc:contributor> <dcterms:issued>2015-04-14</dcterms:issued> <dc:contributor>Myin-Germeys, Inez</dc:contributor> <dc:contributor>Prüßner, Jens</dc:contributor> <dc:contributor>Collip, Dina</dc:contributor> <dc:creator>Collip, Dina</dc:creator> <dc:contributor>van Amelsvoort, Therese</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-04-18T07:43:18Z</dcterms:available> <dc:language>eng</dc:language> <dc:creator>Booij, Jan</dc:creator> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/38497"/> <dc:creator>Heinzel, Alexander</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-04-18T07:43:18Z</dc:date> <dc:creator>Winz, Oliver</dc:creator> <dcterms:abstract xml:lang="eng">Stress is an important risk factor in the etiology of psychotic disorder. Preclinical work has shown that stress primarily increases dopamine (DA) transmission in the frontal cortex. Given that DA-mediated hypofrontality is hypothesized to be a cardinal feature of psychotic disorder, stress-related extrastriatal DA release may be altered in psychotic disorder. Here we quantified for the first time stress-induced extrastriatal DA release and the spatial extent of extrastriatal DA release in individuals with non-affective psychotic disorder (NAPD). Twelve healthy volunteers (HV) and 12 matched drug-free NAPD patients underwent a single infusion [(18)F]fallypride positron emission tomography scan during which they completed the control and stress condition of the Montreal Imaging Stress Task. HV and NAPD did not differ in stress-induced [(18)F]fallypride displacement and the spatial extent of stress-induced [(18)F]fallypride displacement in medial prefrontal cortex (mPFC) and temporal cortex (TC). In the whole sample, the spatial extent of stress-induced radioligand displacement in right ventro-mPFC, but not dorso-mPFC or TC, was positively associated with task-induced subjective stress. Psychotic symptoms during the scan or negative, positive and general subscales of the Positive and Negative Syndrome Scale were not associated with stress-induced [(18)F]fallypride displacement nor the spatial extent of stress-induced [(18)F]fallypride displacement in NAPD. Our results do not offer evidence for altered stress-induced extrastriatal DA signaling in NAPD, nor altered functional relevance. The implications of these findings for the role of the DA system in NAPD and stress processing are discussed.</dcterms:abstract> <dcterms:rights rdf:resource="http://nbn-resolving.de/urn:nbn:de:bsz:352-20150914100631302-4485392-8"/> <dc:creator>Shali, Siamak Mohammadkhani</dc:creator> <dc:contributor>Heinzel, Alexander</dc:contributor> <dc:creator>Prüßner, Jens</dc:creator> <dc:contributor>Kasanova, Zuzana</dc:contributor> <dc:contributor>Shali, Siamak Mohammadkhani</dc:contributor> <dc:creator>van Amelsvoort, Therese</dc:creator> <dc:creator>Hernaus, Dennis</dc:creator> <dcterms:title>No evidence for attenuated stress-induced extrastriatal dopamine signaling in psychotic disorder</dcterms:title> <dc:creator>Myin-Germeys, Inez</dc:creator> <dc:contributor>Booij, Jan</dc:contributor> <dc:contributor>Hernaus, Dennis</dc:contributor> <dc:creator>Kasanova, Zuzana</dc:creator> </rdf:Description> </rdf:RDF>

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