Type of Publication: | Journal article |
Publication status: | Published |
URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-2-92d864e211aa9 |
Author: | Boccardi, Marina; Bocchetta, Martina; Apostolova, Liana G.; Barnes, Josephine; Bartzokis, George; Corbetta, Gabriele; DeCarli, Charles; deToledo-Morrell, Leyla; Pruessner, Jens C.; Frisoni, Giovanni B. et al. |
Year of publication: | 2015 |
Published in: | Alzheimer's & Dementia ; 11 (2015), 2. - pp. 126-138. - ISSN 1552-5260. - eISSN 1552-5279 |
Pubmed ID: | 25130658 |
DOI (citable link): | https://dx.doi.org/10.1016/j.jalz.2014.02.009 |
Summary: |
Background
This study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures, to define standard operating procedures for magnetic resonance (MR)-based manual hippocampal segmentation. Methods The panel received a questionnaire regarding whole hippocampus boundaries and segmentation procedures. Quantitative information was supplied to allow evidence-based answers. A recursive and anonymous Delphi procedure was used to achieve convergence. Significance of agreement among panelists was assessed by exact probability on Fisher's and binomial tests. Results Agreement was significant on the inclusion of alveus/fimbria (P = .021), whole hippocampal tail (P = .013), medial border of the body according to visible morphology (P = .0006), and on this combined set of features (P = .001). This definition captures 100% of hippocampal tissue, 100% of Alzheimer’s disease-related atrophy, and demonstrated good reliability on preliminary intrarater (0.98) and inter-rater (0.94) estimates. Discussion Consensus was achieved among international experts with respect to hippocampal segmentation using MR resulting in a harmonized segmentation protocol. |
Subject (DDC): | 150 Psychology |
Keywords: | Hippocampus; Atrophy; Volumetry; Manual segmentation; Harmonization; Anatomical landmarks; Delphi procedure; Alzheimer's disease; Medial temporal lobe; Hippocampal atrophy; Magnetic resonance; Neuroimaging; Standard operational procedures; Enrichment; MCI; Reliability |
Link to License: | In Copyright |
BOCCARDI, Marina, Martina BOCCHETTA, Liana G. APOSTOLOVA, Josephine BARNES, George BARTZOKIS, Gabriele CORBETTA, Charles DECARLI, Leyla DETOLEDO-MORRELL, Jens C. PRUESSNER, Giovanni B. FRISONI, 2015. Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance. In: Alzheimer's & Dementia. 11(2), pp. 126-138. ISSN 1552-5260. eISSN 1552-5279. Available under: doi: 10.1016/j.jalz.2014.02.009
@article{Boccardi2015-02Delph-38496, title={Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance}, year={2015}, doi={10.1016/j.jalz.2014.02.009}, number={2}, volume={11}, issn={1552-5260}, journal={Alzheimer's & Dementia}, pages={126--138}, author={Boccardi, Marina and Bocchetta, Martina and Apostolova, Liana G. and Barnes, Josephine and Bartzokis, George and Corbetta, Gabriele and DeCarli, Charles and deToledo-Morrell, Leyla and Pruessner, Jens C. and Frisoni, Giovanni B.} }
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