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Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance

Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance

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BOCCARDI, Marina, Martina BOCCHETTA, Liana G. APOSTOLOVA, Josephine BARNES, George BARTZOKIS, Gabriele CORBETTA, Charles DECARLI, Leyla DETOLEDO-MORRELL, Jens C. PRUESSNER, Giovanni B. FRISONI, 2015. Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance. In: Alzheimer's & Dementia. 11(2), pp. 126-138. ISSN 1552-5260. eISSN 1552-5279

@article{Boccardi2015-02Delph-38496, title={Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance}, year={2015}, doi={10.1016/j.jalz.2014.02.009}, number={2}, volume={11}, issn={1552-5260}, journal={Alzheimer's & Dementia}, pages={126--138}, author={Boccardi, Marina and Bocchetta, Martina and Apostolova, Liana G. and Barnes, Josephine and Bartzokis, George and Corbetta, Gabriele and DeCarli, Charles and deToledo-Morrell, Leyla and Pruessner, Jens C. and Frisoni, Giovanni B.} }

eng Bartzokis, George Bartzokis, George Bocchetta, Martina DeCarli, Charles Apostolova, Liana G. Boccardi, Marina Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance 2015-02 Barnes, Josephine Apostolova, Liana G. deToledo-Morrell, Leyla Frisoni, Giovanni B. deToledo-Morrell, Leyla Pruessner, Jens C. Background<br /><br />This study aimed to have international experts converge on a harmonized definition of whole hippocampus boundaries and segmentation procedures, to define standard operating procedures for magnetic resonance (MR)-based manual hippocampal segmentation.<br /><br />Methods<br /><br />The panel received a questionnaire regarding whole hippocampus boundaries and segmentation procedures. Quantitative information was supplied to allow evidence-based answers. A recursive and anonymous Delphi procedure was used to achieve convergence. Significance of agreement among panelists was assessed by exact probability on Fisher's and binomial tests.<br /><br />Results<br /><br />Agreement was significant on the inclusion of alveus/fimbria (P = .021), whole hippocampal tail (P = .013), medial border of the body according to visible morphology (P = .0006), and on this combined set of features (P = .001). This definition captures 100% of hippocampal tissue, 100% of Alzheimer’s disease-related atrophy, and demonstrated good reliability on preliminary intrarater (0.98) and inter-rater (0.94) estimates.<br /><br />Discussion<br /><br />Consensus was achieved among international experts with respect to hippocampal segmentation using MR resulting in a harmonized segmentation protocol. Barnes, Josephine Corbetta, Gabriele Frisoni, Giovanni B. Corbetta, Gabriele Bocchetta, Martina DeCarli, Charles 2017-04-18T07:21:28Z Boccardi, Marina Pruessner, Jens C. 2017-04-18T07:21:28Z

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