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Survey of protocols for the manual segmentation of the hippocampus : preparatory steps towards a joint EADC-ADNI harmonized protocol

Survey of protocols for the manual segmentation of the hippocampus : preparatory steps towards a joint EADC-ADNI harmonized protocol

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BOCCARDI, Marina, Rossana GANZOLA, Martina BOCCHETTA, Michela PIEVANI, Alberto REDOLFI, George BARTZOKIS, Richard CAMICIOLI, John G CSERNANSKY, Jens C. PRUESSNER, Giovanni B. FRISONI, 2011. Survey of protocols for the manual segmentation of the hippocampus : preparatory steps towards a joint EADC-ADNI harmonized protocol. In: Journal of Alzheimer's disease : JAD. 26(Suppl 3), pp. 61-75. ISSN 1387-2877. eISSN 1875-8908. Available under: doi: 10.3233/JAD-2011-0004

@article{Boccardi2011Surve-38480, title={Survey of protocols for the manual segmentation of the hippocampus : preparatory steps towards a joint EADC-ADNI harmonized protocol}, year={2011}, doi={10.3233/JAD-2011-0004}, number={Suppl 3}, volume={26}, issn={1387-2877}, journal={Journal of Alzheimer's disease : JAD}, pages={61--75}, author={Boccardi, Marina and Ganzola, Rossana and Bocchetta, Martina and Pievani, Michela and Redolfi, Alberto and Bartzokis, George and Camicioli, Richard and Csernansky, John G and Pruessner, Jens C. and Frisoni, Giovanni B.} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/38480"> <dc:contributor>Redolfi, Alberto</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/38480"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Bartzokis, George</dc:creator> <dc:creator>Boccardi, Marina</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-04-12T09:17:57Z</dcterms:available> <dc:creator>Ganzola, Rossana</dc:creator> <dc:creator>Frisoni, Giovanni B.</dc:creator> <dcterms:abstract xml:lang="eng">Manual segmentation from magnetic resonance imaging (MR) is the gold standard for evaluating hippocampal atrophy in Alzheimer's disease (AD). Nonetheless, different segmentation protocols provide up to 2.5-fold volume differences. Here we surveyed the most frequently used segmentation protocols in the AD literature as a preliminary step for international harmonization. The anatomical landmarks (anteriormost and posteriormost slices, superior, inferior, medial, and lateral borders) were identified from 12 published protocols for hippocampal manual segmentation ([Abbreviation] first author, publication year: [B] Bartzokis, 1998; [C] Convit, 1997; [dTM] deToledo-Morrell, 2004; [H] Haller, 1997; [J] Jack, 1994; [K] Killiany, 1993; [L] Lehericy, 1994; [M] Malykhin, 2007; [Pa] Pantel, 2000; [Pr] Pruessner, 2000; [S] Soininen, 1994; [W] Watson, 1992). The hippocampi of one healthy control and one AD patient taken from the 1.5T MR ADNI database were segmented by a single rater according to each protocol. The accuracy of the protocols' interpretation and translation into practice was checked with lead authors of protocols through individual interactive web conferences. Semantically harmonized landmarks and differences were then extracted, regarding: (a) the posteriormost slice, protocol [B] being the most restrictive, and [H, M, Pa, Pr, S] the most inclusive; (b) inclusion [C, dTM, J, L, M, Pr, W] or exclusion [B, H, K, Pa, S] of alveus/fimbria; (c) separation from the parahippocampal gyrus, [C] being the most restrictive, [B, dTM, H, J, Pa, S] the most inclusive. There were no substantial differences in the definition of the anteriormost slice. This survey will allow us to operationalize differences among protocols into tracing units, measure their impact on the repeatability and diagnostic accuracy of manual hippocampal segmentation, and finally develop a harmonized protocol.</dcterms:abstract> <dc:creator>Csernansky, John G</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Bocchetta, Martina</dc:contributor> <dc:contributor>Pruessner, Jens C.</dc:contributor> <dc:contributor>Camicioli, Richard</dc:contributor> <dc:contributor>Csernansky, John G</dc:contributor> <dcterms:issued>2011</dcterms:issued> <dcterms:title>Survey of protocols for the manual segmentation of the hippocampus : preparatory steps towards a joint EADC-ADNI harmonized protocol</dcterms:title> <dc:creator>Pievani, Michela</dc:creator> <dc:creator>Camicioli, Richard</dc:creator> <dc:contributor>Boccardi, Marina</dc:contributor> <dc:contributor>Frisoni, Giovanni B.</dc:contributor> <dc:creator>Redolfi, Alberto</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/43"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/43"/> <dc:contributor>Pievani, Michela</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-04-12T09:17:57Z</dc:date> <dc:contributor>Bartzokis, George</dc:contributor> <dc:creator>Bocchetta, Martina</dc:creator> <dc:creator>Pruessner, Jens C.</dc:creator> <dc:contributor>Ganzola, Rossana</dc:contributor> <dc:language>eng</dc:language> </rdf:Description> </rdf:RDF>

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