Target mediated drug disposition with drug–drug interaction, Part II: competitive and uncompetitive cases

Koch, Gilbert; Jusko, William J.; Schropp, Johannes

Target mediated drug disposition with drug–drug interaction, Part II: competitive and uncompetitive cases

Files

Koch_2-omapw5xpv0x05.pdf(2.66 MB)

Date

2017

Authors

Koch, Gilbert

Jusko, William J.

Schropp, Johannes

Publication type

Journal article

Publication status

Published

Published in

Journal of Pharmacokinetics and Pharmacodynamics ; 44 (2017), 1. - pp. 27-42. - ISSN 1567-567X. - eISSN 1573-8744

Abstract

We present competitive and uncompetitive drug-drug interaction (DDI) with target mediated drug disposition (TMDD) equations and investigate their pharmacokinetic DDI properties. For application of TMDD models, quasi-equilibrium (QE) or quasi-steady state (QSS) approximations are necessary to reduce the number of parameters. To realize those approximations of DDI TMDD models, we derive an ordinary differential equation (ODE) representation formulated in free concentration and free receptor variables. This ODE formulation can be straightforward implemented in typical PKPD software without solving any non-linear equation system arising from the QE or QSS approximation of the rapid binding assumptions. This manuscript is the second in a series to introduce and investigate DDI TMDD models and to apply the QE or QSS approximation.

Subject (DDC)

510 Mathematics

Keywords

Drug–drug interaction, Target-mediated drug disposition, Competitive, Uncompetitive

Cite This

ISO 690

KOCH, Gilbert, William J. JUSKO, Johannes SCHROPP, 2017. Target mediated drug disposition with drug–drug interaction, Part II: competitive and uncompetitive cases. In: Journal of Pharmacokinetics and Pharmacodynamics. 44(1), pp. 27-42. ISSN 1567-567X. eISSN 1573-8744. Available under: doi: 10.1007/s10928-016-9502-0

BibTex

@article{Koch2017-02Targe-38417,
  year={2017},
  doi={10.1007/s10928-016-9502-0},
  title={Target mediated drug disposition with drug–drug interaction, Part II: competitive and uncompetitive cases},
  number={1},
  volume={44},
  issn={1567-567X},
  journal={Journal of Pharmacokinetics and Pharmacodynamics},
  pages={27--42},
  author={Koch, Gilbert and Jusko, William J. and Schropp, Johannes}
}

RDF

<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/38417">
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/38417"/>
    <dc:creator>Jusko, William J.</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/39"/>
    <dc:creator>Koch, Gilbert</dc:creator>
    <dc:contributor>Jusko, William J.</dc:contributor>
    <dc:language>eng</dc:language>
    <dc:creator>Schropp, Johannes</dc:creator>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-04-07T08:38:33Z</dcterms:available>
    <dc:contributor>Schropp, Johannes</dc:contributor>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-04-07T08:38:33Z</dc:date>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/38417/1/Koch_2-omapw5xpv0x05.pdf"/>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/38417/1/Koch_2-omapw5xpv0x05.pdf"/>
    <dc:rights>terms-of-use</dc:rights>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/39"/>
    <dcterms:abstract xml:lang="eng">We present competitive and uncompetitive drug-drug interaction (DDI) with target mediated drug disposition (TMDD) equations and investigate their pharmacokinetic DDI properties. For application of TMDD models, quasi-equilibrium (QE) or quasi-steady state (QSS) approximations are necessary to reduce the number of parameters. To realize those approximations of DDI TMDD models, we derive an ordinary differential equation (ODE) representation formulated in free concentration and free receptor variables. This ODE formulation can be straightforward implemented in typical PKPD software without solving any non-linear equation system arising from the QE or QSS approximation of the rapid binding assumptions. This manuscript is the second in a series to introduce and investigate DDI TMDD models and to apply the QE or QSS approximation.</dcterms:abstract>
    <dcterms:issued>2017-02</dcterms:issued>
    <dc:contributor>Koch, Gilbert</dc:contributor>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dcterms:title>Target mediated drug disposition with drug–drug interaction, Part II: competitive and uncompetitive cases</dcterms:title>
  </rdf:Description>
</rdf:RDF>

Bibliography of Konstanz

Yes