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Prenatal maternal stress from a natural disaster predicts hippocampus volumes in males at age 11 : Project Ice Storm

Prenatal maternal stress from a natural disaster predicts hippocampus volumes in males at age 11 : Project Ice Storm

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DUFOIX, Romane, Arnaud CHARIL, David P. LAPLANTE, Tomáš PAUS, Jens PRÜSSNER, Suzanne KING, 2015. Prenatal maternal stress from a natural disaster predicts hippocampus volumes in males at age 11 : Project Ice Storm. In: International Journal of Developmental Neuroscience. 47(Part A), pp. 12. ISSN 0736-5748. eISSN 1873-474X. Available under: doi: 10.1016/j.ijdevneu.2015.04.042

@article{Dufoix2015-12Prena-38397, title={Prenatal maternal stress from a natural disaster predicts hippocampus volumes in males at age 11 : Project Ice Storm}, year={2015}, doi={10.1016/j.ijdevneu.2015.04.042}, number={Part A}, volume={47}, issn={0736-5748}, journal={International Journal of Developmental Neuroscience}, author={Dufoix, Romane and Charil, Arnaud and Laplante, David P. and Paus, Tomáš and Prüßner, Jens and King, Suzanne} }

Prüßner, Jens Charil, Arnaud Prenatal maternal stress from a natural disaster predicts hippocampus volumes in males at age 11 : Project Ice Storm 2015-12 Charil, Arnaud Laplante, David P. Paus, Tomáš 2017-04-07T06:46:54Z King, Suzanne King, Suzanne Dufoix, Romane Introduction<br /><br />The hippocampus develops primarily during the fetal period and plays a pivotal role in learning and memory. Non-human primate studies have demonstrated that early and late in utero exposure to maternal stress results in reduced hippocampal volumes. However, no human prospective studies of the effects of prenatal maternal stress (PNMS) on the hippocampal development have been conducted.<br /><br />Objective<br /><br />To determine whether in utero exposure to disaster-related PNMS is associated with altered hippocampal volumes in 11½-year-old children. We hypothesized that higher maternal objective and/or subjective PNMS levels would be related to smaller hippocampal volumes.<br /><br />Methods<br /><br />Measures of maternal objective (i.e., events the women experienced) and subjective (i.e., the women's psychological response to the crisis) PNMS were obtained after the 1998 Quebec Ice Storm. We obtained T1-weighted images of 33 males and 32 female 11½ year olds. Hippocampal segmentations from native MRI scans were performed using the automatic SACHA method. The number of obstetric complications was recorded using hospital records.<br /><br />Results<br /><br />Overall, more obstetric complications were related to smaller right hippocampal volumes (RHCV. Higher levels of maternal objective PNMS were related to smaller RHCV in males only. Inspection of the objective hardship × obstetric complication interaction revealed that males exposed to high levels of objective hardship or obstetric complications or both had smaller RHCV compared to males exposed to low levels of objective hardship and obstetric complications.<br /><br />Conclusions<br /><br />Our results suggest that higher levels of disaster-related objective PNMS, but not subjective PNMS are related to smaller RHCV in male but not female adolescents. It remains to be determined whether this alteration in RHCV in 11½ years old males is related to observable phenotypes. Prüßner, Jens Laplante, David P. eng 2017-04-07T06:46:54Z Dufoix, Romane Paus, Tomáš

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