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The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance : Evidence of validity

The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance : Evidence of validity

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FRISONI, Giovanni B., Clifford R. JACK, Martina BOCCHETTA, Corinna BAUER, Kristian S. FREDERIKSEN, Yawu LIU, Gregory PREBOSKE, Tim SWIHART, Jens C. PRUESSNER, Bengt WINBLAD, 2015. The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance : Evidence of validity. In: Alzheimer's & Dementia. 11(2), pp. 111-125. ISSN 1552-5260. eISSN 1552-5279. Available under: doi: 10.1016/j.jalz.2014.05.1756

@article{Frisoni2015-02EADCA-38372, title={The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance : Evidence of validity}, year={2015}, doi={10.1016/j.jalz.2014.05.1756}, number={2}, volume={11}, issn={1552-5260}, journal={Alzheimer's & Dementia}, pages={111--125}, author={Frisoni, Giovanni B. and Jack, Clifford R. and Bocchetta, Martina and Bauer, Corinna and Frederiksen, Kristian S. and Liu, Yawu and Preboske, Gregory and Swihart, Tim and Pruessner, Jens C. and Winblad, Bengt} }

Pruessner, Jens C. Preboske, Gregory The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance : Evidence of validity Frisoni, Giovanni B. Jack, Clifford R. Swihart, Tim Frederiksen, Kristian S. 2017-04-06T08:41:18Z 2015-02 Bauer, Corinna Bauer, Corinna Bocchetta, Martina Winblad, Bengt Pruessner, Jens C. Jack, Clifford R. Liu, Yawu Winblad, Bengt Background<br /><br />An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance.<br /><br />Methods<br /><br />Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web-platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T.<br /><br />Results<br /><br />The agreement among tracers was relatively low with the local protocols (absolute left/right ICC 0.44/0.43) and much higher with the HarP (absolute left/right ICC 0.88/0.89). On the larger set of 15 cases, the HarP agreement within (left/right ICC range: 0.94/0.95 to 0.99/0.99) and among tracers (left/right ICC range: 0.89/0.90) was very high. The volume variance due to different tracers was 0.9% of the total, comparing favorably to variance due to scanner manufacturer (1.2), atrophy rates (3.5), hemispheric asymmetry (3.7), field strength (4.4), and significantly smaller than the variance due to atrophy (33.5%, P < .001), and physiological variability (49.2%, P < .001).<br /><br />Conclusions<br /><br />The HarP has high measurement stability compared with local segmentation protocols, and good reproducibility within and among human tracers. Hippocampi segmented with the HarP can be used as a reference for the qualification of human tracers and automated segmentation algorithms. Frederiksen, Kristian S. Bocchetta, Martina Swihart, Tim Preboske, Gregory Frisoni, Giovanni B. 2017-04-06T08:41:18Z eng Liu, Yawu

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