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Blunted cortisol awakening response in men with first episode psychosis : Relationship to parental bonding

Blunted cortisol awakening response in men with first episode psychosis : Relationship to parental bonding

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PRUESSNER, Marita, Nadia VRACOTAS, Ridha JOOBER, Jens C. PRUESSNER, Ashok K. MALLA, 2013. Blunted cortisol awakening response in men with first episode psychosis : Relationship to parental bonding. In: Psychoneuroendocrinology. 38(2), pp. 229-240. ISSN 0306-4530. eISSN 1873-3360. Available under: doi: 10.1016/j.psyneuen.2012.06.002

@article{Pruessner2013-02Blunt-38357, title={Blunted cortisol awakening response in men with first episode psychosis : Relationship to parental bonding}, year={2013}, doi={10.1016/j.psyneuen.2012.06.002}, number={2}, volume={38}, issn={0306-4530}, journal={Psychoneuroendocrinology}, pages={229--240}, author={Pruessner, Marita and Vracotas, Nadia and Joober, Ridha and Pruessner, Jens C. and Malla, Ashok K.} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/38357"> <dc:creator>Pruessner, Jens C.</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:issued>2013-02</dcterms:issued> <dc:contributor>Vracotas, Nadia</dc:contributor> <dc:contributor>Pruessner, Jens C.</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/43"/> <dcterms:abstract xml:lang="eng">Early life adversity has been associated with an increased risk for the development of mental health problems, including psychotic disorders, perhaps mediated by a changed regulation of the Hypothalamic Pituitary Adrenal (HPA) axis. Aim of the present study was to confirm our previous finding of an attenuated cortisol awakening response (CAR) in men with first episode psychosis (FEP) and to explore a possible link between a blunted CAR and early adversity as indicated by perceived parental bonding. Fifty-eight patients (38 men, 20 women; mean age 23.25±3.86) with a FEP and 33 healthy community controls (16 men, 17 women; mean age 22.91±3.64) participated in the study. Saliva samples for assessment of the CAR were collected immediately, 30 and 60min after awakening. Complete cortisol samples were available in a reduced sample of 56 patients (37 men) and 30 controls (13 men). Parental bonding during the first 16 years of life was assessed retrospectively with the Parental Bonding Inventory. Results showed a significantly blunted CAR in male compared to female patients, confirming our previously reported findings. We also found a lower CAR in the total FEP group compared to controls, which failed to reach significance after controlling for time of awakening. A significantly lower percentage of patients than controls reported optimal maternal parenting. Within the patient group, significantly fewer male than female patients reported optimal maternal and paternal parenting. Only in patients, unfavorable paternal parenting was related to a blunted CAR. Dysregulation of the HPA axis in male patients might be a consequence of non-optimal parenting and contribute to the less favorable course of psychosis in men compared to women.</dcterms:abstract> <dcterms:title>Blunted cortisol awakening response in men with first episode psychosis : Relationship to parental bonding</dcterms:title> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-04-06T07:40:51Z</dcterms:available> <dc:contributor>Joober, Ridha</dc:contributor> <dc:creator>Vracotas, Nadia</dc:creator> <dc:language>eng</dc:language> <dc:creator>Pruessner, Marita</dc:creator> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/38357"/> <dc:creator>Joober, Ridha</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/43"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-04-06T07:40:51Z</dc:date> <dc:contributor>Pruessner, Marita</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Malla, Ashok K.</dc:creator> <dc:contributor>Malla, Ashok K.</dc:contributor> </rdf:Description> </rdf:RDF>

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