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Manual segmentation of the fornix, fimbria, and alveus on high-resolution 3T MRI : application via fully-automated mapping of the human memory circuit white and grey matter in healthy and pathological aging

Manual segmentation of the fornix, fimbria, and alveus on high-resolution 3T MRI : application via fully-automated mapping of the human memory circuit white and grey matter in healthy and pathological aging

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AMARAL, Robert S.C., Min Tae M. PARK, Gabriel A. DEVENYI, Vivian LYNN, Jon PIPITONE, Julie WINTERBURN, Sofia CHAVEZ, Mark SCHIRA, Jens C. PRUESSNER, M. Mallar CHAKRAVARTY, 2016. Manual segmentation of the fornix, fimbria, and alveus on high-resolution 3T MRI : application via fully-automated mapping of the human memory circuit white and grey matter in healthy and pathological aging. In: NeuroImage. ISSN 1053-8119. eISSN 1095-9572. Available under: doi: 10.1016/j.neuroimage.2016.10.027

@article{Amaral2016-10Manua-38183, title={Manual segmentation of the fornix, fimbria, and alveus on high-resolution 3T MRI : application via fully-automated mapping of the human memory circuit white and grey matter in healthy and pathological aging}, year={2016}, doi={10.1016/j.neuroimage.2016.10.027}, issn={1053-8119}, journal={NeuroImage}, author={Amaral, Robert S.C. and Park, Min Tae M. and Devenyi, Gabriel A. and Lynn, Vivian and Pipitone, Jon and Winterburn, Julie and Chavez, Sofia and Schira, Mark and Pruessner, Jens C. and Chakravarty, M. Mallar} }

Winterburn, Julie Amaral, Robert S.C. Chakravarty, M. Mallar Park, Min Tae M. Chakravarty, M. Mallar Pruessner, Jens C. 2016-10 Pruessner, Jens C. Chavez, Sofia Pipitone, Jon 2017-03-28T13:58:15Z Manual segmentation of the fornix, fimbria, and alveus on high-resolution 3T MRI : application via fully-automated mapping of the human memory circuit white and grey matter in healthy and pathological aging Devenyi, Gabriel A. Chavez, Sofia Devenyi, Gabriel A. Schira, Mark Pipitone, Jon Amaral, Robert S.C. Lynn, Vivian Recently, much attention has been focused on the definition and structure of the hippocampus and its subfields, while the projections from the hippocampus have been relatively understudied. Here, we derive a reliable protocol for manual segmentation of hippocampal white matter regions (alveus, fimbria, and fornix) using high-resolution magnetic resonance images that are complementary to our previous definitions of the hippocampal subfields, both of which are freely available at https://github.com/cobralab/atlases. Our segmentation methods demonstrated high inter- and intra-rater reliability, were validated as inputs in automated segmentation, and were used to analyze the trajectory of these regions in both healthy aging (OASIS), and Alzheimer's disease (AD) and mild cognitive impairment (MCI; using ADNI). We observed significant bilateral decreases in the fornix in healthy aging while the alveus and cornu ammonis (CA) 1 were well preserved (all p's<0.006). MCI and AD demonstrated significant decreases in fimbriae and fornices. Many hippocampal subfields exhibited decreased volume in both MCI and AD, yet no significant differences were found between MCI and AD cohorts themselves. Our results suggest a neuroprotective or compensatory role for the alveus and CA1 in healthy aging and suggest that an improved understanding of the volumetric trajectories of these structures is required. Lynn, Vivian eng Winterburn, Julie 2017-03-28T13:58:15Z Park, Min Tae M. Schira, Mark

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