Type of Publication: | Journal article |
Publication status: | Published |
URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-0-400556 |
Author: | Schoemaker, Dorothee; Poirier, Judes; Escobar, Sophia; Gauthier, Serge; Pruessner, Jens |
Year of publication: | 2016 |
Published in: | Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring ; 2 (2016). - pp. 132-139. - eISSN 2352-8729 |
Pubmed ID: | 27239534 |
DOI (citable link): | https://dx.doi.org/10.1016/j.dadm.2015.11.007 |
Summary: |
Introduction
Familiarity has been associated with integrity of the rhinal cortex. Thus, impairment in familiarity is expected in very early stages of Alzheimer's disease (AD). The apolipoprotein E (APOE) ε4 allele is a major risk factor for AD. Here, we investigated the effect of the APOE ε4 status on familiarity in cognitively normal aging individuals. Methods Eighty-one individuals aged between 55 and 80 years, 21 carriers and 60 noncarriers, were used in these analyses. A cognitive evaluation was performed on all participants to document the absence of objective cognitive deficits. The effect of APOE ε4 status on familiarity was tested using independent sample t test and an analysis of covariance controlling for age, gender, and education. Results The groups did not differ in term of age, education, and male/female ratio. APOE ε4 carriers showed a significant reduction in familiarity. No other cognitive deficit was observed in the group of ε4 carriers, relative to noncarriers. Discussion APOE ε4 is associated with a reduction in familiarity in the absence of other cognitive deficits. These results suggest that performance in familiarity could represent an early cognitive marker for individuals at risk of AD. |
Subject (DDC): | 150 Psychology |
Link to License: | In Copyright |
Bibliography of Konstanz: | Yes |
SCHOEMAKER, Dorothee, Judes POIRIER, Sophia ESCOBAR, Serge GAUTHIER, Jens PRUESSNER, 2016. Selective familiarity deficits in otherwise cognitively intact aging individuals with genetic risk for Alzheimer's disease. In: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 2, pp. 132-139. eISSN 2352-8729. Available under: doi: 10.1016/j.dadm.2015.11.007
@article{Schoemaker2016Selec-38161, title={Selective familiarity deficits in otherwise cognitively intact aging individuals with genetic risk for Alzheimer's disease}, year={2016}, doi={10.1016/j.dadm.2015.11.007}, volume={2}, journal={Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring}, pages={132--139}, author={Schoemaker, Dorothee and Poirier, Judes and Escobar, Sophia and Gauthier, Serge and Pruessner, Jens} }
Pruessner_0-400556.pdf | 137 |