Activation of the glmS Ribozyme Confers Bacterial Growth Inhibition

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SCHÜLLER, Anna, Daniel MATZNER, Christina E. LÜNSE, Valentin WITTMANN, Catherine SCHUMACHER, Sandra UNSLEBER, Heike BRÖTZ-OESTERHELT, Christoph MAYER, Gabriele BIERBAUM, Günter MAYER, 2017. Activation of the glmS Ribozyme Confers Bacterial Growth Inhibition. In: ChemBioChem. 18(5), pp. 435-440. ISSN 1439-4227. eISSN 1439-7633

@article{Schuller2017-03-02Activ-37503, title={Activation of the glmS Ribozyme Confers Bacterial Growth Inhibition}, year={2017}, doi={10.1002/cbic.201600491}, number={5}, volume={18}, issn={1439-4227}, journal={ChemBioChem}, pages={435--440}, author={Schüller, Anna and Matzner, Daniel and Lünse, Christina E. and Wittmann, Valentin and Schumacher, Catherine and Unsleber, Sandra and Brötz-Oesterhelt, Heike and Mayer, Christoph and Bierbaum, Gabriele and Mayer, Günter} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/37503"> <dc:creator>Schüller, Anna</dc:creator> <dc:contributor>Mayer, Günter</dc:contributor> <dcterms:abstract xml:lang="eng">The ever-growing number of pathogenic bacteria resistant to treatment with antibiotics call for the development of novel compounds with as-yet unexplored modes of action. Here, we demonstrate the in vivo antibacterial activity of carba-α-d-glucosamine (CGlcN). In this mode of action study, we provide evidence that CGlcN-mediated growth inhibition is due to glmS ribozyme activation, and we demonstrate that CGlcN hijacks an endogenous activation pathway, hence utilizing a prodrug mechanism. This is the first report describing antibacterial activity mediated by activating the self-cleaving properties of a ribozyme. Our results open the path towards a compound class with an entirely novel and distinct molecular mechanism.</dcterms:abstract> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-02-16T10:18:00Z</dc:date> <dc:contributor>Matzner, Daniel</dc:contributor> <dc:creator>Lünse, Christina E.</dc:creator> <dcterms:issued>2017-03-02</dcterms:issued> <dc:contributor>Bierbaum, Gabriele</dc:contributor> <dc:creator>Mayer, Günter</dc:creator> <dc:contributor>Mayer, Christoph</dc:contributor> <dc:creator>Unsleber, Sandra</dc:creator> <dcterms:title>Activation of the glmS Ribozyme Confers Bacterial Growth Inhibition</dcterms:title> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/37503"/> <dc:creator>Schumacher, Catherine</dc:creator> <dc:contributor>Schüller, Anna</dc:contributor> <dc:contributor>Schumacher, Catherine</dc:contributor> <dc:creator>Matzner, Daniel</dc:creator> <dc:creator>Wittmann, Valentin</dc:creator> <dc:creator>Mayer, Christoph</dc:creator> <dc:creator>Brötz-Oesterhelt, Heike</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-02-16T10:18:00Z</dcterms:available> <dc:contributor>Wittmann, Valentin</dc:contributor> <dc:contributor>Lünse, Christina E.</dc:contributor> <dc:creator>Bierbaum, Gabriele</dc:creator> <dc:language>eng</dc:language> <dc:contributor>Brötz-Oesterhelt, Heike</dc:contributor> <dc:contributor>Unsleber, Sandra</dc:contributor> </rdf:Description> </rdf:RDF>

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