Activation of the glmS Ribozyme Confers Bacterial Growth Inhibition


Dateien zu dieser Ressource

Dateien Größe Format Anzeige

Zu diesem Dokument gibt es keine Dateien.

SCHÜLLER, Anna, Daniel MATZNER, Christina E. LÜNSE, Valentin WITTMANN, Catherine SCHUMACHER, Sandra UNSLEBER, Heike BRÖTZ-OESTERHELT, Christoph MAYER, Gabriele BIERBAUM, Günter MAYER, 2017. Activation of the glmS Ribozyme Confers Bacterial Growth Inhibition. In: ChemBioChem. 18(5), pp. 435-440. ISSN 1439-4227. eISSN 1439-7633

@article{Schuller2017-03-02Activ-37503, title={Activation of the glmS Ribozyme Confers Bacterial Growth Inhibition}, year={2017}, doi={10.1002/cbic.201600491}, number={5}, volume={18}, issn={1439-4227}, journal={ChemBioChem}, pages={435--440}, author={Schüller, Anna and Matzner, Daniel and Lünse, Christina E. and Wittmann, Valentin and Schumacher, Catherine and Unsleber, Sandra and Brötz-Oesterhelt, Heike and Mayer, Christoph and Bierbaum, Gabriele and Mayer, Günter} }

<rdf:RDF xmlns:rdf="" xmlns:bibo="" xmlns:dc="" xmlns:dcterms="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dc:creator>Schüller, Anna</dc:creator> <dc:contributor>Mayer, Günter</dc:contributor> <dcterms:abstract xml:lang="eng">The ever-growing number of pathogenic bacteria resistant to treatment with antibiotics call for the development of novel compounds with as-yet unexplored modes of action. Here, we demonstrate the in vivo antibacterial activity of carba-α-d-glucosamine (CGlcN). In this mode of action study, we provide evidence that CGlcN-mediated growth inhibition is due to glmS ribozyme activation, and we demonstrate that CGlcN hijacks an endogenous activation pathway, hence utilizing a prodrug mechanism. This is the first report describing antibacterial activity mediated by activating the self-cleaving properties of a ribozyme. Our results open the path towards a compound class with an entirely novel and distinct molecular mechanism.</dcterms:abstract> <dc:date rdf:datatype="">2017-02-16T10:18:00Z</dc:date> <dc:contributor>Matzner, Daniel</dc:contributor> <dc:creator>Lünse, Christina E.</dc:creator> <dcterms:issued>2017-03-02</dcterms:issued> <dc:contributor>Bierbaum, Gabriele</dc:contributor> <dc:creator>Mayer, Günter</dc:creator> <dc:contributor>Mayer, Christoph</dc:contributor> <dc:creator>Unsleber, Sandra</dc:creator> <dcterms:title>Activation of the glmS Ribozyme Confers Bacterial Growth Inhibition</dcterms:title> <bibo:uri rdf:resource=""/> <dc:creator>Schumacher, Catherine</dc:creator> <dc:contributor>Schüller, Anna</dc:contributor> <dc:contributor>Schumacher, Catherine</dc:contributor> <dc:creator>Matzner, Daniel</dc:creator> <dc:creator>Wittmann, Valentin</dc:creator> <dc:creator>Mayer, Christoph</dc:creator> <dc:creator>Brötz-Oesterhelt, Heike</dc:creator> <dcterms:available rdf:datatype="">2017-02-16T10:18:00Z</dcterms:available> <dc:contributor>Wittmann, Valentin</dc:contributor> <dc:contributor>Lünse, Christina E.</dc:contributor> <dc:creator>Bierbaum, Gabriele</dc:creator> <dc:language>eng</dc:language> <dc:contributor>Brötz-Oesterhelt, Heike</dc:contributor> <dc:contributor>Unsleber, Sandra</dc:contributor> </rdf:Description> </rdf:RDF>

Das Dokument erscheint in:

KOPS Suche


Mein Benutzerkonto