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Osteopontin Stabilizes Metastable States Prior to Nucleation during Apatite Formation

Osteopontin Stabilizes Metastable States Prior to Nucleation during Apatite Formation

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IBSEN, Casper Jon Steenberg, Denis GEBAUER, Henrik BIRKEDAL, 2016. Osteopontin Stabilizes Metastable States Prior to Nucleation during Apatite Formation. In: Chemistry of Materials. 28(23), pp. 8550-8555. ISSN 0897-4756. eISSN 1520-5002

@article{Ibsen2016-12-13Osteo-37237, title={Osteopontin Stabilizes Metastable States Prior to Nucleation during Apatite Formation}, year={2016}, doi={10.1021/acs.chemmater.6b01088}, number={23}, volume={28}, issn={0897-4756}, journal={Chemistry of Materials}, pages={8550--8555}, author={Ibsen, Casper Jon Steenberg and Gebauer, Denis and Birkedal, Henrik} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/37237"> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/37237"/> <dc:language>eng</dc:language> <dcterms:title>Osteopontin Stabilizes Metastable States Prior to Nucleation during Apatite Formation</dcterms:title> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-02-09T07:43:19Z</dcterms:available> <dcterms:issued>2016-12-13</dcterms:issued> <dc:creator>Gebauer, Denis</dc:creator> <dcterms:abstract xml:lang="eng">Osteopontin, which is a phosphoprotein with strong ties to in vivo bone mineralization, is shown to change the precipitation pathway of calcium phosphate. We show that the presence of the phosphoprotein, even in minute concentrations, can stabilize an otherwise oversaturated mixture against precipitation. At moderate concentrations, we find that the protein introduces a new intermediate state into the reaction pathway leading to apatite formation. This new intermediate was found to share many characteristics of a coacervate or polymer-induced liquid-like precursor (PILP) phase. Our results show that these types of complex phases should be considered when discussing the mechanisms of bone mineralization on a subcellular level.</dcterms:abstract> <dc:contributor>Ibsen, Casper Jon Steenberg</dc:contributor> <dc:creator>Ibsen, Casper Jon Steenberg</dc:creator> <dc:creator>Birkedal, Henrik</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2017-02-09T07:43:19Z</dc:date> <dc:contributor>Gebauer, Denis</dc:contributor> <dc:contributor>Birkedal, Henrik</dc:contributor> </rdf:Description> </rdf:RDF>

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