Assessment of non-linear combination effect terms for drug-drug interactions


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KOCH, Gilbert, Johannes SCHROPP, William J. JUSKO, 2016. Assessment of non-linear combination effect terms for drug-drug interactions. In: Journal of Pharmacokinetics and Pharmacodynamics. 43(5), pp. 461-479. ISSN 0090-466X. eISSN 1573-8744. Available under: doi: 10.1007/s10928-016-9490-0

@article{Koch2016-10Asses-36991, title={Assessment of non-linear combination effect terms for drug-drug interactions}, year={2016}, doi={10.1007/s10928-016-9490-0}, number={5}, volume={43}, issn={0090-466X}, journal={Journal of Pharmacokinetics and Pharmacodynamics}, pages={461--479}, author={Koch, Gilbert and Schropp, Johannes and Jusko, William J.} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dc:creator>Jusko, William J.</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Koch, Gilbert</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:issued>2016-10</dcterms:issued> <dc:date rdf:datatype="">2017-01-30T14:29:25Z</dc:date> <dcterms:isPartOf rdf:resource=""/> <dc:contributor>Schropp, Johannes</dc:contributor> <dcterms:title>Assessment of non-linear combination effect terms for drug-drug interactions</dcterms:title> <dc:creator>Schropp, Johannes</dc:creator> <dcterms:available rdf:datatype="">2017-01-30T14:29:25Z</dcterms:available> <dc:contributor>Koch, Gilbert</dc:contributor> <dcterms:abstract xml:lang="eng">Drugs interact with their targets in different ways. A diversity of modeling approaches exists to describe the combination effects of two drugs. We investigate several combination effect terms (CET) regarding their underlying mechanism based on drug-receptor binding kinetics, empirical and statistical summation principles and indirect response models. A list with properties is provided and the interrelationship of the CETs is analyzed. A method is presented to calculate the optimal drug concentration pair to produce the half-maximal combination effect. This work provides a comprehensive overview of typically applied CETs and should shed light into the question as to which CET is appropriate for application in pharmacokinetic/pharmacodynamic models to describe a specific drug-drug interaction mechanism.</dcterms:abstract> <dc:contributor>Jusko, William J.</dc:contributor> <bibo:uri rdf:resource=""/> <dspace:isPartOfCollection rdf:resource=""/> <dc:language>eng</dc:language> </rdf:Description> </rdf:RDF>

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