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Norepinephrine infusion without but not with alpha-adrenergic blockade by phentolamine increases coagulation parameter levels in healthy men

Norepinephrine infusion without but not with alpha-adrenergic blockade by phentolamine increases coagulation parameter levels in healthy men

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WIRTZ, Petra H., Claudia ZUCCARELLA-HACKL, Nadja HEIMGARTNER, Ulrike EHLERT, Roland VON KANEL, 2016. Norepinephrine infusion without but not with alpha-adrenergic blockade by phentolamine increases coagulation parameter levels in healthy men. In: Psychoneuroendocrinology. 71(Supplement), pp. 45-46. ISSN 0306-4530. eISSN 1873-3360

@article{Wirtz2016-09Norep-36983, title={Norepinephrine infusion without but not with alpha-adrenergic blockade by phentolamine increases coagulation parameter levels in healthy men}, year={2016}, doi={10.1016/j.psyneuen.2016.07.120}, number={Supplement}, volume={71}, issn={0306-4530}, journal={Psychoneuroendocrinology}, pages={45--46}, author={Wirtz, Petra H. and Zuccarella-Hackl, Claudia and Heimgartner, Nadja and Ehlert, Ulrike and von Kanel, Roland} }

2016-09 2017-01-30T13:55:05Z Wirtz, Petra H. eng Zuccarella-Hackl, Claudia von Kanel, Roland Zuccarella-Hackl, Claudia Background: Mental stress induces reliable increases in coagulation parameters including fibrinogen or D-dimer, but underlying mechanisms are not fully understood. While stress-induced D-dimer increases correlate with norepinephrine (NE) secretion, a potential role of noradrenergic mechanisms remains unclear. Here, we investigated in humans, whether a NE-stress-reactivity mimicking NE-infusion with and without alpha-adrenergic blockade by phentolamine would induce changes in different coagulation parameters.<br /><br />Methods: In a single-blind placebo-controlled within-subjects design, 18 healthy men (33–64 years) took part in three different experimental trials varying in terms of substance infusion with a 1-min first infusion followed by a 15-min second infusion: saline-infusion (trial-1), NE infusion (5microg/min) without alpha-adrenergic blockade (trial-2), and with phentolamine-induced non-selective blockade of alpha1- and alpha2-adrenergic receptors (trial-3). Blood samples were collected immediately before, and several times after substance infusion to measure fibrinogen, FVIII:C, and D-dimer.<br /><br />Results: As compared to placebo-infusion (trial-1), NE-infusion without alpha-adrenergic blockade (trial-2) induced higher fibrinogen and D-dimer reactivity (p's < 009). Alpha-adrenergic blockade (trial-3) reduced coagulation parameter reactivity to NE-infusion: trial-3 did not significantly differ from both other trials (p's > 09).<br /><br />Conclusions: We found that NE-infusion stimulates coagulation activity and that this stimulation was in part inhibited by non-selective alpha-adrenergic blockade by phentolamine. This suggests that the mechanisms underlying stress-induced coagulation activity increases may involve NE and alpha-adrenergic receptors. Norepinephrine infusion without but not with alpha-adrenergic blockade by phentolamine increases coagulation parameter levels in healthy men Ehlert, Ulrike von Kanel, Roland Ehlert, Ulrike 2017-01-30T13:55:05Z Wirtz, Petra H. Heimgartner, Nadja Heimgartner, Nadja

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